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Breakthrough in the understanding of how pancreatic cancer cells ingest nutrients points to new drug target

May 13, 2013 ? In a landmark cancer study published online in Nature, researchers at NYU School of Medicine have unraveled a longstanding mystery about how pancreatic tumor cells feed themselves, opening up new therapeutic possibilities for a notoriously lethal disease with few treatment options. Pancreatic cancer kills nearly 38,000 Americans annually, making it a leading cause of cancer death. The life expectancy for most people diagnosed with it is less than a year.

Now new research reveals a possible chink in the armor of this recalcitrant disease. Many cancers, including pancreatic, lung, and colon cancer, feature a mutated protein known as Ras that plays a central role in a complex molecular chain of events that drives cancer cell growth and proliferation. It is well known that Ras cancer cells have special nutrient requirements to grow and survive. But how Ras cells cope to actually meet their extraordinary nutrient requirements has been poorly understood -- until now. In the study, led by Cosimo Commisso, a postdoctoral fellow in the Department of Biochemistry and Molecular Pharmacology at NYU School of Medicine, show for the first time how Ras cancer cells exploit a process called macropinocytosis to swallow up the protein albumin, which cells then harvest for amino acids essential for growth.

"A big mystery is how certain tumors meet their excessive nutrient demands ," says Dr. Commisso, whose work is funded in part by the Pancreatic Cancer Action Network. "We believe they accomplish this by macropinocytosis."

The findings suggest that Ras cancer cells are particularly dependent on macropinocytosis for growth and survival. When the researchers used a chemical to block the uptake of albumin via macropinocytosis in mice with pancreatic tumors, the tumors stopped growing and in some cases even shrank. Moreover, pancreatic cancer cells in mice featured more macropinosomes -- the vesicles that transport nutrients deep into a cell -- than normal mouse cells.

The discovery of a "protein eating" mechanism unique to some cancer cells sets the stage for drugs that could block the engulfing process without causing collateral damage to healthy cells and suggests new ways to ferry chemotherapeutic cargo into the heart of cancer cells.

"This work offers up a completely different way to target cancer metabolism," says lead principal investigator of the study Dafna Bar-Sagi, PhD, senior vice president and vice dean for Science, chief scientific officer and professor, Department of Biochemistry and Molecular Pharmacology, NYU Langone Medical Center, who first identified macropinocytosis in Ras-transformed cancer cells. "It's exciting to think that we can cause the demise of some cancer cells simply by blocking this nutrient delivery process."

Crucial to the team's findings is the work of Matthew G. Vander Heiden, assistant professor of biology at the David H. Koch Institute for Integrative Cancer Research at MIT and Christian Metallo, assistant professor of bioengineering at the University of California at San Diego, who characterized how Ras cells derive energy from the constituent amino acids released after protein engulfment.

Other key contributors include Craig B. Thompson, president and CEO of the Sloan-Kettering Cancer Center and Joshua D. Rabinowitz, professor of chemistry at the Lewis Sigler Institute for Integrative Genomics at Princeton University.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/NCzfeSHn-QI/130513095020.htm

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DNA test shows Ohio kidnap suspect fathered girl

CLEVELAND (AP) ? As relatives of the Cleveland kidnapping and rape suspect recounted claims of his unnerving paranoia and violent outbursts, DNA testing confirmed the man who allegedly held three women captive for nearly a decade is the father of a 6-year-old girl who escaped from the house along with the women.

Ariel Castro, charged with rape and kidnapping, remained jailed Friday under a suicide watch on $8 million bond while prosecutors weighed more charges, including some that might carry the death penalty. Public defender Kathleen Demetz, who said she is acting as Castro's adviser while he awaits a full-time attorney, said Friday she can't speak to his guilt or innocence and said only that she advised him not to talk to reporters.

But those who know the 52-year-old Castro are speaking up, saying he was often angry, paranoid and prone to violent outbursts against the mother of his children. He frequently beat her, played bizarre psychological games and locked her indoors, they said.

The stories, repeated in separate interviews with The Associated Press by members of Castro's extended family, have surprised people who knew him as a musician who played bass in several bands around Cleveland the last two decades.

Miguel Quinones, manager of a group Castro played with twice as a backup bass player about five years ago, said he had nothing bad to say about Castro based on his own experiences.

But in the interviews, some of Castro's ex-relatives said he frequently flashed his compulsions for secrecy and terrifying rage that often led him to beat his common-law wife, Grimilda Figueroa.

Figueroa left Castro years ago and died in 2012 after a long illness. Their early years together were happy, but something inside Castro snapped after the birth of their first child, they said.

Castro pushed her down the stairs, fractured her ribs, broke her nose several times, cracked a tooth and dislocated both shoulders, they said. In one incident, he shoved Figueroa into a cardboard box and closed the flaps over her head, they said. He kept her and children imprisoned, cut off from friends and family, and Figueroa couldn't even unlock her own front door, they said.

Figueroa filed domestic-violence complaints, accusing Castro of threatening many times to kill her and her daughters. She charged that he frequently abducted the children and kept them from her, even though she had full custody, with no visitation rights for Castro.

"When I go over there to visit her, and I ask her, 'Nilda, I'm here, open the door,' she's like, 'I can't. Ariel has the key,'" Figueroa's sister, Elida Caraballo, recalled.

Two of the women freed from Castro's home, including the one who gave birth to the girl, returned to relatives' houses earlier this week. The third woman, Michelle Knight, was released from a hospital Friday with a request that her privacy be respected.

"Michelle Knight is in good spirits and would like the community to know that she is extremely grateful for the outpouring of flowers and gifts," the statement said.

On Friday, Knight's grandmother, Deborah King, visited the home of one of the captives, Gina DeJesus, to meet the DeJesus family.

She said she loved and missed Knight, "And if I get to, she's going to get the biggest hug and kiss from me that she ever did have."

A police report alleged that Castro impregnated one of his captives at least five times and made her miscarry by starving her and punching her in the stomach. The report also said another one of the women, Amanda Berry, was forced to give birth in a plastic kiddie pool.

Tests by the state attorney general's office on a sample of Castro's DNA confirmed he fathered Berry's 6-year-old daughter, who was rescued from his house, the office said Friday. After her release, the girl returned home with the 27-year-old Berry. Officials also were entering the DNA profile into a national database to see if it links him to other crimes.

The three women said Castro chained them up in the basement but eventually let them live on the home's second floor. Each woman told a similar story about being abducted after accepting a ride from him.

The FBI has not recovered human remains in its search of the house, spokeswoman Vicki Anderson said Friday. Agents removed more than 200 pieces of evidence, she added, declining to say what was found.

Berry and former captive Gina DeJesus, 22, went home with relatives Wednesday.

The AP does not usually name people alleging sexual assault without their consent, but the names of the three women were widely circulated by their families, the media and law enforcement for years.

___

Associated Press writers Meghan Barr, Mike Householder, Thomas J. Sheeran and Andrew Welsh-Huggins and AP freelance writer John Coyne in Cleveland; Brendan Farrington in Florida; and Dan Sewell in Cincinnati contributed to this report along with news researcher Rhonda Shafner in New York.

Source: http://news.yahoo.com/dna-test-shows-ohio-kidnap-suspect-fathered-girl-062758995.html

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Quantum Computer Kicks PC Ass in First Ever Head-to-Head Test

Scientists often claim that quantum computers will blow the competition away in the coming years?and now the world's first head-to-head test has shown they leave regular PCs reeling in their wake.

Quantum computer use the idea of quantum bits, called qubits, that can theoretically take the value of 0 and 1 at the same time?unlike normal digital computers that can only take one state. It's that blurring of 0s and 1s that gives rise to the claims of speed. But while quantum computers sound futuristic, there are already a handful of systems in existence. It's not yet clear that these devices are genuine quantum computers?it's actually impossible to tell whether they genuinely make use of the physics of quantum entanglement when they're running?but they're certainly based on the appropriate theory.

Now, D-Wave, which makes one of these quantum computers, has let Catherine McGeoch of Amherst College, Massachusetts, test it against a "high-end desktop computer". The D-Wave hardware is designed to solve a special kind of optimization problem, by minimizing the solution of a complicated equation?an incredibly common computer science puzzle. New Scientist describes how the competition went:

McGeoch gave each system roughly half a second to find the best solution to a version of the optimisation problem, and repeated the trial with 100 different versions. She then did the experiment for problems involving even more variables and a more complicated equation.

The D-Wave computer found the best solution every time within half a second. The three regular algorithms struggled to keep up for problems with more than 100 or so variables. The best of the three, CPLEX, had to run for half an hour to match D-Wave's performance on the largest problems.

That's 3,600 times longer?quite some difference. Of course, it's debatable as to whether it's a fair test: the quantum computer specializes in solving the problem, whereas the PCs are true all-rounders. But when thrown other kinds of problems, the quantum computer did match or outperform the other computers, too. Evidence, then, that quantum computers really do kick ass?it just might still be a few years before you lay your hands on one. [New Scientist]

Image by D-Wave

Source: http://gizmodo.com/quantum-computer-kicks-pc-ass-in-first-ever-head-to-hea-499681531

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House passes tactical Republican debt bill

By Rachelle Younglai

WASHINGTON (Reuters) - Republicans in the House of Representatives passed a bill on Thursday that would require the Obama administration to prioritize government debt payments and retirement benefits if Congress fails to reach a deal to raise the U.S. debt ceiling.

The legislation is not expected to go anywhere in the Democratic-controlled Senate and the White House has said it will veto the bill, but what is essentially a tactical maneuver will allow the Republicans, who control the House, to argue they have done their best to avoid a potential U.S. credit default.

By the end of next week, the Obama administration will no longer be able to borrow money to fund government operations because Congress has only agreed to extend the government's borrowing authority until May 19.

This will force the U.S. Treasury to start using its limited accounting maneuvers to extend the debt limit but such measures are not permanent and analysts say they could be exhausted by October.

The Republican bill, which passed 221-207 with a few Republicans dissenting and no Democratic support, would allow the U.S. Treasury to borrow more funds to pay the interest and principal on government bonds as well as retirement benefits.

Democrats called it the "pay China first" legislation as the Asian country holds more than $1.2 trillion in U.S. government bonds and is America's largest foreign creditor.

The bill "says we should pay the government of China before we pay our troops, before we pay our veterans, before we pay other bills here in the United States," said Chris Van Hollen, the top Democrat on the House Budget Committee.

But Republicans argued that it would take the threat of default off the table.

"Financial markets ought to be confident that their Treasury bonds are safe, regardless of what political storms are raging in Washington," said Republican Representative Tom McClintock of California, who crafted the original version of the bill.

REPUBLICAN STRATEGY

House Republicans are looking for ways to deal with the debt limit while staying true to House Speaker John Boehner's rule that any debt-cap increase be matched by budget cuts and reforms.

The Republicans have been trying to force the administration to slash government spending and reform Medicare and Social Security benefits in return for an increase in the debt ceiling.

However, with no deal along those lines in sight, some allies of chief Republican tax writer Dave Camp, a representative from Michigan, have floated the idea of linking a debt-limit increase to a revamp of the tax code and lower tax rates.

This would allow lawmakers to skirt the politically painful decisions to cut Medicare and Social Security.

However, it is unclear if mainstream party supporters, much less the conservative faction of the Republican Party, will go along with this.

"It wouldn't be enough," said Kevin Brady, a senior Republican from Texas who is on Camp's tax-writing committee.

He said reform of the Social Security and Medicare benefits programs still would be required.

Camp has been working for more than a year to draft an overhaul of the entire tax code and has vowed repeatedly to move legislation out of his Ways and Means Committee this year.

House Republican are due to hold a meeting next Wednesday to discuss the various options.

(Additional reporting by Kim Dixon; Editing by David Brunnstrom and Bill Trott)

Source: http://news.yahoo.com/house-set-pass-tactical-republican-debt-bill-050736930.html

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Today in History

Today is Friday, May 10, the 130th day of 2013. There are 235 days left in the year.

Today's Highlight in History:

On May 10, 1863, during the Civil War, Confederate Lt. Gen. Thomas "Stonewall" Jackson died of pneumonia, a complication resulting from being hit by friendly fire eight days earlier during the Battle of Chancellorsville in Virginia.

On this date:

In 1774, Louis XVI acceded to the throne of France.

In 1775, Ethan Allen and his Green Mountain Boys, along with Col. Benedict Arnold, captured the British-held fortress at Ticonderoga, N.Y.

In 1865, Union forces captured Confederate President Jefferson Davis in Irwinville, Ga.

In 1869, a golden spike was driven in Promontory, Utah, marking the completion of the first transcontinental railroad in the United States.

In 1913, the U.S. House of Representatives passed a resolution calling upon all federal officials, from the president on down, to wear a white carnation the following day in observance of Mother's Day.

In 1924, J. Edgar Hoover was given the job of FBI director.

In 1933, the Nazis staged massive public book burnings in Germany.

In 1941, Adolf Hitler's deputy, Rudolf Hess, parachuted into Scotland on what he claimed was a peace mission. (Hess ended up serving a life sentence at Spandau prison until 1987, when he apparently committed suicide.)

In 1963, the Rolling Stones recorded their first single for Decca Records in London, covering Chuck Berry's "Come On" (which ended up being redone) and "I Want to Be Loved" by Willie Dixon.

In 1973, the New York Knicks won the NBA Finals, defeating the Los Angeles Lakers in Game 5, 102-93.

In 1984, the International Court of Justice said the United States should halt any actions to blockade Nicaragua's ports (the U.S. had already said it would not recognize World Court jurisdiction on this issue).

In 1993, members of the Senate Armed Services Committee visited the Norfolk Naval Base in Virginia for a hearing on the issue of homosexuals in the military; most of the sailors who spoke said they favored keeping the ban on gays. At least 188 workers were killed in a doll factory fire in Bangkok, Thailand.

Ten years ago: The leader of Iraq's largest Shiite (SHEE'-eyet) Muslim group, Ayatollah Mohammad Baqir al-Hakim (BAH'-keer ahl hah-KEEM'), returned triumphantly to his U.S.-occupied homeland after two decades in Iranian exile. The New York Times announced on its website that one of its reporters, Jayson Blair, had "committed frequent acts of journalistic fraud."

Five years ago: Barack Obama erased Hillary Rodham Clinton's once-imposing lead among Democratic superdelegates as he added endorsements from Utah, Ohio and the Virgin Islands. A tornado in Picher, Okla., killed at least seven people. Jenna Bush married Henry Hager, the son of a Virginia Republican party official, at the Bush family ranch in Crawford, Texas.

One year ago: Republican presidential candidate Mitt Romney apologized for "stupid" high school pranks that might have gone too far and moved quickly to stamp out any notion that he'd bullied schoolmates because they were gay. JPMorgan Chase said it had lost $2 billion in six weeks in a trading portfolio designed to hedge against risks the company took with its own money. In Syria, twin suicide car bombs exploded outside a military intelligence building, killing 55 people. Carroll Shelby, 89, the legendary car designer, died in Dallas.

Today's Birthdays: Author Bel Kaufman ("Up the Down Staircase") is 102. Author Barbara Taylor Bradford is 80. Rhythm-and-blues singer Henry Fambrough (The Spinners) is 75. TV-radio personality Gary Owens is 74. Actor David Clennon is 70. Writer-producer-director Jim Abrahams is 69. Singer Donovan is 67. Singer Dave Mason is 67. Actor Bruce Penhall is 56. Former Sen. Rick Santorum, R-Pa., is 55. Actress Victoria Rowell is 54. Rock singer Bono (BAH'-noh) (U2) is 53. Rock musician Danny Carey (Tool) is 52. Actor Darryl M. Bell is 50. Playwright Suzan-Lori Parks is 50. Model Linda Evangelista is 48. Rapper Young MC is 46. Actor Erik Palladino is 45. Rock singer Richard Patrick (Filter) is 45. Actor Lenny Venito is 44. Actor-singer Todd Lowe is 41. Country musician David Wallace (Cole Deggs and the Lonesome) is 41. Actress Andrea Anders is 38. Race car driver Helio Castroneves is 38. Rock musician Jesse Vest is 36. Actor Kenan Thompson is 35. Rhythm-and-blues singer Jason Dalyrimple (Soul For Real) is 33. Rock musician Joey Zehr (The Click Five) is 30. Singer Ashley Poole (Dream) is 28. Actress Odette Annable is 28. Actress Lauren Potter is 23. Olympic gold medal swimmer Missy Franklin is 18.

Thought for Today: "The art of being wise is the art of knowing what to overlook." ? William James, American psychologist and philosopher (1842-1910).

(Above Advance for Use Friday, May 10)

Source: http://news.yahoo.com/today-history-050206767.html

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FTSE LIVE: Footsie extends winning run after Japan stocks soar overnight; BT the biggest riser

By This Is Money Reporters

PUBLISHED: 02:35 EST, 10 May 2013 | UPDATED: 04:39 EST, 10 May 2013

10.25: The Footsie climbs a little further, up 22 points now (0.34 per cent) to 6,615.

BT's better-than-expected results have boosted its shares 10 per cent now, up to 304p. Read our full report here.

British Airways parent company International Airlines Group edged lower after reporting a bigger first quarter loss, driven by the poor performance of its Iberia business. Shares were 4.05p lower at 276.45p.

Outside the top flight, Ocado shares jumped 14 per cent after Goldman Sachs upgraded the stock to buy and the internet grocer's management said they were encouraged by progress so far this year.

Eye on the ball: BT just announced a free sports deal for broadband customers; its shares have shot up today

The stock, which fell sharply yesterday on fears a distribution deal with Morrisons will fall through, rose by 31.1p to 239.65p to place the stock at the top of the FTSE 250 index.

Alastair McCaig, market analyst at IG, said: 'The FTSE has been dragged to new five-year highs by buoyant European markets, which continue to climb.

'In Asia, the Nikkei continues to demonstrate the fine form shown in April, and with US dollar finally breaking the psychological 100 yen level the Japanese index could be set for new highs.

'BT have followed up yesterday?s aggressive pricing policy by posting impressive full-year figures. Many UK armchair sports fans will be hoping that they can instigate a pricing war with Sky. With a host of well-known sports personalities endorsing them, BT will hope to improve their market share of broadband users. However, if BT don?t have the product to back up the hype customers could be hard to hang onto - as both Des Lynam & Setanta will testify.

'The UK high street's banking market could be thrown into fresh chaos after the Co-op's credit rating was slashed by Moody?s overnight. Any lingering hopes the UK government had that the Co-op would acquire its 632 Lloyds branches have now surely dissipated.'

Read more on this here.

08.15: The FTSE 100 has extended its winning run into a seventh straight session, led by telecoms group BT on robust results and with some traders forecasting more market gains to come.

The Footsie was up 14 points, or 0.2 per cent, at 6,607 in early trading, having risen 0.1 per cent yesterday to record its highest close since October 2007.

The UK benchmark has risen around 12 per cent this year as interest rate cuts and injections of liquidity by central banks around the world have lifted equity markets in spite of a stuttering global economy.

'I still think the fundamentals (aren't good enough) to warrant the current stock prices, (but) the central bank intervention has more than offset that,' Nick Xanders, head of European equity strategy at BTIG, said.

'At some point that will give and the fundamentals will matter again, but it isn't today.'

BT jumped 8.5 per cent, rebounding from a 2.3 per cent drop on Thursday, as it raised its outlook after cost cuts and strong consumer demand helped it to beat annual forecasts. Its shares are up 23.5p to 299.2p.

BofA Merrill Lynch, describing BT's results as 'very strong', upgraded its rating on the stock to 'buy'.?

08.00: Japanese equities soared to five-and-a-half year highs overnight, with the dollar sailing past the symbolic 100 yen level and beefing up the outlook for corporate Japan, but shares elsewhere in Asia retreated as global equities paused overnight from recent rallies. ?

Financial spreadbetters predicted London's FTSE 100, Paris's CAC-40 and Frankfurt's DAX? would open up as much as 0.2 per cent.

Yesterday the pan-European FTSEurofirst closed flat overnight to stay near five-year highs.

US stock futures were up 0.1 per cent, suggesting a slightly firmer Wall Street open after American stocks slipped from record highs yesterday.

?

The dollar was buoyed after Thursday's weekly US data showed initial jobless claims fell to the lowest level in more than five years, following last week's much stronger-than-expected monthly non-farm payrolls report for April.? ?

'What you need to understand about what is going on in the United States is that we're growing, this recovery is real. There may be some bumps, but the fundamental push forward is there,' said Carl Larry, president of the Houston-based Oil Outlook and Opinions.

The yen's resumed downtrend bodes well for Japanese exporters, and expectations of robust earnings drove the Nikkei stock average up 3 per cent to its highest since January 2008.

The index is up 6.4 per cent, on track for its biggest weekly gain since December 2009 when it jumped 10.4 per cent.

?

Source: http://www.dailymail.co.uk/money/markets/article-2322348/FTSE-LIVE-Footsie-extends-winning-run-Japan-stocks-soar-overnight-BT-biggest-riser.html?ITO=1490&ns_mchannel=rss&ns_campaign=1490

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Was Goldberg's WWE run successful?

It?s hard to believe it?s been a decade since Goldberg showed up on Raw for the first time. Back then ? in the years after WCW buckled under mounting debt and WWE was left as the only relevant company in sports-entertainment ? the former WCW Champion was the most exciting WWE acquisition since Chris Jericho jumped ship in 1999. And, yet, Goldberg?s tenure is widely regarded as a disappointment.

Photos of Goldberg in WWE?|?Watch Goldberg's best WWE matches

Goldberg may not be a huge part of the sports-entertainment conversation today, but he?s surprisingly relevant for a guy who hasn?t been active since his infamous WrestleMania XX bout against Brock Lesnar in 2004. Almost ten years removed from that bizarre night, audiences are still fascinated by the competitor who once went on a 173 match winning streak in WCW. To this day, Goldberg?s name remains one of the most searched terms on WWE.com.

Figuring out why that?s the case isn?t difficult. At a time when the most vital cross-section of WCW?s roster was made up of previously established, 40-something stars like Hulk Hogan, Randy Savage and Lex Luger, Goldberg arrived as a wholly original main event talent. There were a few things about his persona that didn?t feel fresh ? there happened to be another guy who was doing the bald head, goatee and black trunks thing already ? but there was so much about this former NFL defensive tackle that was wildly unexpected.

Goldberg took cues from the mixed martial arts world long before the combat sport reached mainstream prominence. And the name Goldberg ? a surname most closely associated with female comedian Whoopi Goldberg ? wasn?t the moniker of a typical main eventer. In fact, he was nearly known as The Hybrid before deciding to stick with his birthname and inspiring one of sports-entertainment?s most ubiquitous chants.

Most of all, from June 23, 1997, through Dec. 27, 1998, Goldberg did not lose a single match. There?s a growing ideology in sports-entertainment that wins and losses don?t mean much. And, yet, would The Road Warriors have been The Road Warriors if they were getting stomped by The Midnight Express night in and night out? Would Goldberg have been Goldberg if he didn?t flatten Curt Hennig and Saturn with visible ease?

To this very day, Goldberg is romanticized in the quarantine of his thrilling winning streak ? and why not? The powerhouse?s best matches were exercises in humiliation for his opponents. These weren?t traditional mat contests where the momentum shifts dramatically back and forth between competitors. These were flat-out muggings. Sure, his opponents were, by and large, puddings. Perennial losers like Jerry Flynn and Glacier who were speared and jackhammered by Goldberg ad infinitum. But watching these saps get annihilated by a physical, aggressive beast of a man was thrilling.

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Source: http://www.wwe.com/classics/was-goldbergs-wwe-run-successful

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GOVERNMENT OF CANADA HELPING CREATE JOBS BY SUPPORTING NIAGARA MANUFACTURING

2011 was a busy, focused and successful one for our community. There are a number of reasons to say this and I figured important enough to number.

1. Unemployment numbers in our community dropped each and every month since January.

There are still more jobs to create and the recovery is a fragile one. No question however, that we are on the right track.

2. The Cairns Family Health and Biosciences Research Complex was built and is almost completed.

No longer is Brock the university up on the hill. The facility will boast almost 110,000 sq feet of Bioscience research, second to no other research facility or university in the country. It will in fact, rival the facility in place at the University of Florida. The link with the community and our local economy is through the incubator facility that will house small start up businesses. The true value of this investment is when we see the creation of manufacturing jobs through this facility. My close friend Jeff Cairns' dad Roy passed away in 2011.? One of his last significant commitments to his community was the Cairns' family investment and contribution to Brock. Roy had a feeling this is going to work and it's up to all of us to make sure we prove his feeling true.

3. Majority government on May 2nd of this year.

Yes of course, those who didn't vote Conservative may disagree with this from a partisan perspective, but truly what this country needed was a stable federal government for a number of years. We can all judge the results once we reach re-election time in 2015.

4. Completion of a number of economic stimulus projects in town.

The new parking garage, the Armenian community centre, the children's centre at the YMCA, the football/soccer facility at the 4-pad, a brand new airport, nGen technology and multi-media investments, to name a few, have helped bring our community into the modern era. They also created short and long term jobs that were sorely required.

5. St. Catharines/Niagara is at the forefront of the agenda in our nation's capital.

The direction we take as a government is inspired by and involves our community. In other words, we matter and we play a role. I have to compliment both Dean Allison and Justice Minister Rob Nicholson for being great spokespersons for our communities.

Turning to 2012, the economy and continuing to help create jobs will remain our community's most important focus. It's the responsibility of all of us local politicians at the federal, provincial, regional and municipal jurisdictions to work together and never lose sight of the fact that whatever we do must have a long term economic benefit to our city and our Niagara.

We've spent a ton, yes a ton, of taxpayers money in St. Catharines from all orders (levels) of government. All of those investments were made with the rebuilding of our local economy in mind. In other words, we aren't dreamers or creative folks any longer. We are now project managers who have to ensure that taxpayer's investments will do what we (politicians) said it would. In 2012 I'm focused on the results of these investments to ensure that the investors (taxpayers) get value for their hard earned dollars vis-?-vis property tax, regional tax, provincial tax and federal tax. Every one of us has to focus on providing the actual outcomes from each of these investments that prove they're delivering the results promised.

Heading into my 6th year as the MP for our city, I'm looking forward to playing my part and ensuring we do focus on our economy and continue to bring St. Catharines issues to Ottawa.

city I'm looking forward to playing my part and ensuring we do focus on our economy and continue to bring St. Catharines issues to Ottawa.

Here's to 2012!!?

Later,

Discuss this article on the forums. (0 posts)

Source: http://www.rickdykstra.ca/index.php?option=com_content&task=view&id=2822&Itemid=51

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Sony?s E-Book Store Opens In Australia

If you?ve got a Sony e-reader, you?re about to get a whole lot more from your device, because Sony just opened up its e-book store to Aussies.

Sony?s Reader Store officially opened today, and just by signing up, the gadget giant is going to give you a free e-book. You know, provided you want one of the books that Sony is prepared to give away.

The store is accessible from your Sony e-readers, but otherwise, you can head here to get into the new Sony bookstore.

Source: http://www.gizmodo.com.au/2013/05/sonys-e-book-store-opens-in-australia/

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All-in-one Atari 2600 controller crafted to curtail retro gaming clutter

Ahhh, the venerable Atari 2600. The godfather of console gaming has, in recent years, seen a resurgence as a hacker's muse -- mods to its innards and controllers are legion on the web. Recently, a new mod emerged: a controller that combines the capabilities of the Atari's joystick, paddle and keyboard controllers. It's crafted from a small wooden box, a cannibalized joystick, an Ethernet cable, some switches and a smattering of other electronic bits, and there's a full how-to on making one of your own on Instructables, courtesy of user x2Jiggy. If the mere mention of such an all-in-one has those DIY juices flowing, head on past the break for a construction video and see how it's done. It's high time you dust off your stock 2600 and break out Pitfall, Adventure or, well, Breakout.

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Testament to tenacity: NY man nearly finished handwriting King James Bible after 4 years

PHILMONT, N.Y. - In the beginning, Phillip Patterson decided to write out every word in the Bible.

On empty pages, he wrote of Adam, an ark, locusts, loaves, fishes and the resurrection in his neat, looping cursive. Four years of work begat more than 2,400 pages and left a multitude of pens in its wake. Now, as he copies the last words of the last book, Patterson sees all that he has created.

And it is good.

"I hadn't counted on the fact that it would end up being beautiful," Patterson said. "Or that it would be so exhilarating. And so long."

Patterson, 63, might seem like an unlikely scribe for the King James version of the Bible. Tall and bald with a hearty laugh, the retired interior designer is neither monkish nor zealous. He goes to church but has never been particularly religious. Health issues ? including AIDS and anemia ? have sent him to the hospital and slowed the work. He relies on two canes and will lean on walls and furniture to get around his apartment near the Massachusetts border.

But he has always been curious.

One day in 2007, his longtime partner, Mohammad, mentioned that Islam has a tradition of writing out the Qur?an. Patterson replied that the Bible was too long. Mohammad said, well then, Patterson should do it.

"The next day I started researching pens and pencils and paper and never looked back," he said.

Patterson began copying the first five books of the Bible, known as the Pentateuch, in 2007. Work on this "prototype" allowed him to figure out technique, layout and technical details like the type of paper (19-by-13-inch watercolour) and writing instruments (felt-tip pens). He tackled the complete King James Bible in 2009.

Patterson works at a wooden desk by his bed, near neatly shelved pages of his completed volumes. Fingers on his left hand track the words on a small hardcover Bible while he methodically writes with his right hand. Patterson pencils in ruled lines on the sheets to guide his writing and erases them when he is done, leaving black ink on creamy white pages.

The Bible's exact word count depends on who is doing the tallying, but multiple sources put the King James version at around 788,000 words or more. Patterson used to work up to 14 hours a day on the project, though he averages around six to eight hours a day now that his stamina has ebbed. He usually works until he can't stay awake.

"I go to bed and close my eyes and feel so incredibly serene," he said.

There has been darkness and light along the way.

He especially enjoyed the Book of Ruth, which he interprets as people acting loyally and doing the right thing. But he disliked the plagues, killings and other violence scattered throughout the Bible. Although he respects Jesus for promoting peace and love, he finds the character portrayed in the Gospels too glib and condescending to his disciples.

More importantly, the countless hours of transcription has led him to conclude that the Bible is more sublime than just a bunch of stories from thousands of years ago.

"The begetting and the begatting and all of that, that's really incidental," he said. "These people are trying to understand where they fit into this world."

In a way, Patterson is doing the same thing. There were times when he wondered whether he would ever live to finish the project. Now as it nears its end, he said, it has helped him become more patient, more confident, more loving and more open to differences.

"Every day as I write, I discover something new and it expands my mind more and more," Patterson said. "Not so I can become more of a religious person, but so that I can become more of a whole person."

That assessment is echoed by Laura Glazer, a photographer who has documented the project since its start. Glazer, who has become friends with Patterson over the course of some 4,000 pictures, said Patterson has become more introspective since she first started collaborating with him. But she notes that could also be related to the death of Patterson's partner several years ago and the passage of time.

Although rare now, hand-crafted Bibles were common before the invention of the printing press. In those times, monks who made ornate copies of the Bible saw it as part of their sacred calling, said Anthony Tambasco, a professor of theology at Georgetown University. Patterson does not see any kinship to those long-ago scribes, seeing himself merely as a regular guy who ended up learning something.

"He's not a martyr or a saint. That's what's so nice. It's just what he does," Glazer said. "He's not trying to prove anything to anybody. He's making something beautiful."

Patterson will finish up the final lines of the Book of Revelation during a ceremony at his church, St. Peter's Presbyterian, on May 11. His adult daughter and Glazer will be among the guests, and he will discuss the Bible with an eminent theologian. Once the books are bound, the Bible will be given to the church.

Patterson is already talking about turning a new page.

"I will take any opportunity I can find to do this again," he said.

Source: http://news.yahoo.com/testament-tenacity-ny-man-nearly-finished-handwriting-king-084009168.html

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Cooler weather aids fight against Calif. wildfire

Firefighters from Riverside, Calif. work to extinguish a brush fire at Point Mugu, Calif., Friday, May 3, 2013. A Southern California wildfire carving a path to the sea grew to more than 15 square miles and crews prepared Friday for another bad day of gusting winds and searing weather. (AP Photo/Nick Ut)

Firefighters from Riverside, Calif. work to extinguish a brush fire at Point Mugu, Calif., Friday, May 3, 2013. A Southern California wildfire carving a path to the sea grew to more than 15 square miles and crews prepared Friday for another bad day of gusting winds and searing weather. (AP Photo/Nick Ut)

A firefighter keeps watch as the wildfire burns along a hillside in Point Mugu , Calif. Friday, May 3, 2013. Firefighters got a break as gusty winds turned into breezes, but temperatures remained high and humidity levels are expected to soar as cool air moved in from the ocean and the Santa Ana winds retreated. (AP Photo/Ringo H.W. Chiu)

Fire trucks keep an eye on a burned structure at the Naval Base Ventura County (NBVC) at Point Mugu, Calif., Friday, May 3, 2013. The 15 1/2-square-mile blaze was only 10 percent contained on Friday, and the work of more than 900 firefighters, aided by air tankers, was just beginning. (AP Photo/Nick Ut)

A firefighter carries tools down a burned hill after a wildfire in Point Mugu on Friday, May 3, 2013. A huge wildfire carved a path to the sea and burned on the beach Friday, but firefighters got a break as gusty winds turned into breezes. Temperatures remained high, but humidity levels were expected to soar as cool air moved in from the ocean and the Santa Ana winds retreated. (AP Photo/Nick Ut)

A resident waters the burned area next to his home in Point Mugu, Calif., Friday, May 3, 2013. A huge wildfire carved a path to the sea and burned on the beach Friday, but firefighters got a break as gusty winds turned into breezes. Temperatures remained high, but humidity levels were expected to soar as cool air moved in from the ocean and the Santa Ana winds retreated. (AP Photo/Nick Ut)

CAMARILLO, Calif. (AP) ? A big cool-down in weather calmed a huge wildfire burning in Southern California coastal mountains Saturday, and firefighters worked to cut miles of containment lines while conditions were favorable.

High winds and withering hot, dry air were replaced by the normal flow of damp air off the Pacific, significantly reducing fire activity.

"The fire isn't really running and gunning," said Tom Kruschke, a Ventura County Fire Department spokesman.

The 43-square-mile blaze at the western end of the Santa Monica Mountains was 56 percent surrounded.

The humidity level rose so much that an overnight effort to burn away fuel at one section of the fire did not work well, Kruschke said.

Despite the favorable conditions, evacuation orders remained in place for residences in several areas.

Nearly 2,000 firefighters using engines, bulldozers and aircraft worked to corral the blaze.

Firefighting efforts were focused on the fire's east side, rugged canyons that are a mix of public and private lands, Kruschke said.

The National Weather Service said an approaching low pressure system would bring a 20 percent chance of showers Sunday afternoon, with the likelihood increasing into the night and on Monday.

"Anything we get is going to help us," Kruschke said.

The change in the weather was also expected to bring gusty winds to some parts of Southern California, but well away from the fire area.

Despite its size and speed of growth, the fire that broke out Thursday and quickly moved through neighborhoods of Camarillo Springs and Thousand Oaks has caused damage to just 15 homes, though it has threatened thousands.

The fire also swept through Point Mugu State Park, a hiking and camping area that sprawls between those communities and the ocean. Park district Superintendent Craig Sap told the Ventura County Star (http://bit.ly/18CKxY4) that two old, unused ranch-style homes in the backcountry burned. Restrooms and campgrounds also were damaged. Sap estimated repairs would cost $225,000.

The only injuries as of Saturday were a civilian and a firefighter involved in a traffic accident away from the fire.

Residents were grateful so many homes were spared.

"It came pretty close. All of these houses ? these firemen did a tremendous job. Very, very thankful for them," Shayne Poindexter said. Flames came within 30 feet of the house he was building.

On Friday, the wildfire reached the ocean, jumped Pacific Coast Highway and burned a Navy base rifle range on the beach at Point Mugu. When winds reversed direction from offshore to onshore, the fire stormed back up canyons toward inland neighborhoods.

The blaze is one of more than 680 wildfires in the state so far this year ? about 200 more than average.

East of Los Angeles in Riverside County, a new fire that broke out Saturday afternoon burned 650 acres of wilderness south of Banning. It was 20 percent contained. Banning has been flanked by a nearly 5-square-mile fire to the north since Wednesday. Firefighters contained 85 percent of that fire, which destroyed one home shortly after it broke out.

In Northern California, a fire that has blackened more than 10 square miles of wilderness in Tehama County was a threat to 10 unoccupied summer homes near the community of Butte Meadows, according to the California Department of Forestry and Fire Protection.

Thunderstorms Saturday were expected to bring erratic winds but little rain to the area about 200 miles north of San Francisco.

Nearly 1,300 firefighters were on the lines and the blaze, which started Wednesday, was 20 percent contained.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-05-04-California%20Wildfires/id-8b224888e00c48b19c0e8820791af354

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Farrah Abraham Takes Pole Dancing Lessons (PHOTOS)

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Sigma DP2 Merrill

The DP2 Merrill ($999 direct) is one of a trio of fixed-lens cameras?offered by Sigma. They all share the same image sensor, but the focal length of their f/2.8 lenses varies. The DP2 features a lens that produces a standard-angle field of view, perfect for shooters who eschew wide angles. The APS-C Foveon image sensor is a unique design that captures an incredible amount of detail, but requires special software for Raw processing. We liked it a bit better than the DP1 Merrill and DP3 Merrill. Its JPG engine outclasses the DP1 and it's speedier to focus than the DP3, which is slowed by its macro lens. The DP2 will reward you if you work within its limits, and it's the only camera of its type with a standard-angle lens. It doesn't oust the Ricoh GR as our Editors' Choice for prime lens compact cameras. Photos taken with the pocketable GR don't require any special processing, but the lens captures a very different wide-angle field of view that isn't for everyone.

Foveon Image Sensor, Design, and Features
Much like the Sigma DP1 Merrill, the DP2 uses a Foveon X3 image sensor. This design uses three layers to record information,?each one sensitive to a different color channel. Traditional digital cameras use a single-layer sensor with a Bayer overlay, which has grids of red, blue, and green pixels to create a color image. Each layer of the DP2's sensor boasts a 15.4-megapixel resolution?because of this, Sigma advertises it as a 46-megapixel camera, even though the resulting, printable images are limited to 15.4 megapixels in size.

The sensor design omits the low-pass filter, which is a trend on higher-end cameras. But because of its design, which by its nature omits the Bayer color-array filter, there's no danger of moir? entering into your shots. The downside to the unique design is that there's no support for the DP2's Raw format in Lightroom or similar software programs?you'll have to use Sigma's Raw software to process photos. The software leaves a lot to be desired, but you can use it as a basic converter to convert the Raw images into TIFF format, which can then be imported into Lightroom or the workflow application of your choice.

In terms of design, the DP2 is essentially a brick with a lens, measuring 2.6 by 4.8 by 2.3 inches, and weighing in at 11.6 ounces. It's not that far off in size and weight from the 2.7-by-4.9-by-2 inch, 11.2-ounce Leica X2, which has a wider 36mm-equivalent lens. The X2 supports an add-on EVF, which is an option that is not available on the DP2. There is a hot shoe directly above the lens, so using a fixed optical finder that matches its field of view and trusting its autofocus system is an option.

The lens is a 30mm focal length, which translates into 45mm in terms of full-frame photography. It has a maximum aperture of f/2.8, which is a little slow for a standard-angle design. The full-frame Sony Cyber-shot DSC-RX1 has a faster, wider 35mm f/2 lens, but costs nearly three times as much as the Sigma. If you're looking for zoom, look elsewhere, but for those of us who see the world in that focal length, the DP2 is a welcoming camera.

Pleasingly minimal, the camera's color scheme is flat black, with a metal chassis that is cool to the touch. Buttons are labeled in white for shooting functions, and red for playback functions. On top you'll find the Power button, Mode button, a control wheel, and the shutter. The rear houses the Auto Exposure lock, a four-way controller with a center select button (the up direction lets you select the focus mode, the bottom the focus point), an image playback button, a button to control the amount of information shown on the rear display, the menu button, and the QS button.

The QS (Quick Set) button grants access to seven quick shooting controls. Press it once and you can adjust the ISO, exposure compensation, drive mode, and image format settings. Press it a second time and the menu switches to white balance, image compression, color balance, and image format (in the same place as the first menu) settings. It's a well-designed interface, and lets you adjust settings without diving into the menu system.

The 3-inch rear display packs a 920k-dot resolution. It's sharp and gives you a good idea about the quality of the images you are capturing. The display is just as sharp as the 1.2-million-dot display on the Ricoh GR, but it's not as bright; that camera has an extra layer of white pixels that make it possible to view on even the brightest days.

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Internet sales tax bill advances in Senate

DORTMUND, April 24 (Reuters) - Teams for Wednesday's Champions League semi-final first leg between Borussia Dortmund and Real Madrid at BVB stadium. Teams: Borussia Dortmund: 1-Roman Weidenfeller; 26-Lukasz Piszczek, 4-Neven Subotic, 15-Mats Hummels, 29-Marcel Schmelzer; 8-Ilkay Guendogan, 6-Sven Bender, 16-Jakub Blaszczykowski, 10-Mario Goetze, 11-Marco Reus; 9-Robert Lewandowski Real Madrid: 41-Diego Lopez; 4-Sergio Ramos, 3-Pepe, 2-Raphael Varane, 5-Fabio Coentrao; 6-Sami Khedira, 14-Xabi Alonso; 19-Luka Modric, 10-Mesut Ozil, 7-Cristiano Ronaldo; 20-Gonzalo Higuain. ...

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Drug therapy offers high cure rate for 2 hepatitis C subtypes

Apr. 23, 2013 ? A new drug is offering dramatic cure rates for hepatitis C patients with two subtypes of the infection -- genotype 2 and 3, say a team of scientists led by Weill Cornell Medical College researchers. These two subtypes account for approximately 25 percent of hepatitis C infection in the United States.

The drug, called sofosbuvir, offers more effective treatment for most patients studied in a Phase 3 clinical trial who had no other treatment options, report researchers in The New England Journal of Medicine. After three months of combined therapy with sofosbuvir and the antiviral drug ribavirin, the patient response rate for those with genotype 2 was 93 percent, and 61 percent in patients with genotype 3.

This new study is one of several testing new hepatitis C drugs that were published April 23 in an online edition of NEJM. The journal publication coincides with the International Liver Congress 2013 in Amsterdam, the Netherlands, where the results also will be presented.

"The new sofosbuvir therapy offers a much-needed alternative to standard therapy with interferon, which can cause significant side effects for hepatitis C patients," says the study's lead investigator, Dr. Ira Jacobson, chief of the Division of Gastroenterology and Hepatology and Vincent Astor Distinguished Professor of Medicine at Weill Cornell Medical College.

"We have dreamed for years of being able to eliminate interferon from our hepatitis C regimens and this study is one of several that are finally bringing us very close to realizing that goal," says Dr. Jacobson, who is also a gastroenterologist at the Center for Advanced Digestive Care at New York-Presbyterian Hospital/Weill Cornell Medical Center and medical director of the Center for the Study of Hepatitis C, a collaboration between Weill Cornell, NewYork-Presbyterian/Weill Cornell and The Rockefeller University.

The 207 patients enrolled in the clinical trial, known as POSITRON, either did not respond to interferon, could not tolerate it or were unwilling to use it, despite the fact that there were no other treatment options available to them.

"This new treatment represents a paradigm shift in the way that hepatitis C is going to be treated," says Dr. Jacobson. "We are achieving the same or higher cure rates in many patients with sofosbuvir, compared to interferon, and we are doing it in half the time with a drug that has a remarkable safety profile."

Dr. Jacobson estimates that up to half of patients with hepatitis C infection either can't use interferon or don't want to use it. "Sofosbuvir is an extremely promising treatment for this population. It is widely hoped that combinations of potent antiviral drugs will eventually replace the use of interferon, in general, for most hepatitis C patients."

The drug sofosbuvir works by interfering with the ability of the hepatitis C virus to replicate. The drug also confers a high barrier to developing the complication of drug resistance. The U.S. Food and Drug Administration (FDA) has not yet approved sofosbuvir. However, results of the four clinical trials published in the NEJM were used to support the regulatory filing submitted to the FDA by the drug's developer, Gilead Sciences, Inc.

No Treatment Options for Many Patients

Approximately 170 million people are infected with hepatitis C worldwide and 350,000 people die each year from the disease. According to federal statistics, there are an estimated four million people in the U.S. infected with hepatitis C. As there are often no symptoms, most people with hepatitis C are unaware that they are infected.

When left untreated, hepatitis C virus can cause progressive liver disease such as cirrhosis, liver cancer and liver failure. The virus is spread by contact with infected blood, such as through blood transfusions, injection drug use or sexual contact.

There are seven major genotypes of hepatitis C, but most cases are 1, 2 or 3. Genotype 1 is the most common subtype in the U.S. Genotypes 2 and 3 are more common in Europe than in the U.S. and genotype 3 is very prevalent on the Indian subcontinent.

In the study, three-fourths of participants (207) were randomized to treatment with sofosbuvir and ribavirin while one-fourth (71) of participants were randomized to a placebo treatment. All of the patients either did not respond to interferon, or did not want to use it. "This mirrors what happens frequently in the clinic," says Dr. Jacobson. "Between 15 and 30 percent of patients with hepatitis C genotype 2 or 3 infections do not have a response to interferon therapy and do not have alternate treatment options."

Patients were enrolled internationally at 63 sites in the United States, Canada, Australia and New Zealand.

Study results show the response rate for all treated patients with sofosbuvir was 78 percent compared to 0 percent in participants treated with placebo agents. Patients with genotype 2 had a higher cure rate (93 percent) than those with genotype 3 (61 percent), and patients without cirrhosis had a higher response rate (81 percent) compared with participants diagnosed with cirrhosis (61 percent).

The results of another clinical trial, led by Dr. David R. Nelson of the University of Florida at Gainesville, were incorporated into this NEJM manuscript publication. This clinical trial study, called FUSION, was designed to test sofosbuvir and ribavirin in hepatitis C patients with genotype 2 or 3 who had failed interferon therapy.

In FUSION, the drug regimen was tested for both 12 and 16 weeks in patients with genotype 2 or 3. The findings showed that extended use of sofosbuvir resulted in a higher cure rate in both genotypes, but that the difference seen in genotype 3 was highly significant. For genotype 2, 12 versus 16 weeks of treatment resulted in response rates of 86 percent compared to 94 percent; and for genotype 3, the response rates were 30 percent versus 62 percent, respectively.

"Given the absence to date of alternative therapies for patients with genotype 2 or 3 who have failed interferon therapy or for whom it is not an option, treatment with the new sofosbuvir regimen offers a vast improvement," Dr. Jacobson says. "But the optimal duration of treatment for genotype 3 patients, in order to maximize their chance of cure, remains undefined. It could be longer than 16 weeks." Dr. Jacobson adds that future clinical studies will continue to define the optimal length of treatment duration for patients with genotype 3, and that other antiviral drugs in combination with sofosbuvir might shorten the duration of treatment needed to maximize the rates of response.

Both the POSITRON and FUSION studies were funded by Gilead Sciences. Another paper in the same edition of the NEJM reports two additional studies of sofosbuvir-containing therapy, one evaluating a 12 week regimen of peginterferon, ribavirin and sofosbuvir in patients with genotypes 1, 4, 5 and 6 who have never been treated before; the other reporting results of a trial comparing 24 weeks of peginterferon and ribavin with 12 weeks of sofosbuvir and ribavirin in treatment na?ve patients with genotypes 2 and 3.

Dr. Jacobson is a consultant, lecturer and a funded research investigator for Gilead Sciences.

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Story Source:

The above story is reprinted from materials provided by Weill Cornell Medical College.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. Ira M. Jacobson, Stuart C. Gordon, Kris V. Kowdley, Eric M. Yoshida, Maribel Rodriguez-Torres, Mark S. Sulkowski, Mitchell L. Shiffman, Eric Lawitz, Gregory Everson, Michael Bennett, Eugene Schiff, M. Tarek Al-Assi, G. Mani Subramanian, Di An, Ming Lin, John McNally, Diana Brainard, William T. Symonds, John G. McHutchison, Keyur Patel, Jordan Feld, Stephen Pianko, David R. Nelson. Sofosbuvir for Hepatitis C Genotype 2 or 3 in Patients without Treatment Options. New England Journal of Medicine, 2013; : 130423030016000 DOI: 10.1056/NEJMoa1214854

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/HlNlHXEjxRY/130424103134.htm

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