Friday, April 26, 2013

Internet sales tax bill advances in Senate

DORTMUND, April 24 (Reuters) - Teams for Wednesday's Champions League semi-final first leg between Borussia Dortmund and Real Madrid at BVB stadium. Teams: Borussia Dortmund: 1-Roman Weidenfeller; 26-Lukasz Piszczek, 4-Neven Subotic, 15-Mats Hummels, 29-Marcel Schmelzer; 8-Ilkay Guendogan, 6-Sven Bender, 16-Jakub Blaszczykowski, 10-Mario Goetze, 11-Marco Reus; 9-Robert Lewandowski Real Madrid: 41-Diego Lopez; 4-Sergio Ramos, 3-Pepe, 2-Raphael Varane, 5-Fabio Coentrao; 6-Sami Khedira, 14-Xabi Alonso; 19-Luka Modric, 10-Mesut Ozil, 7-Cristiano Ronaldo; 20-Gonzalo Higuain. ...

Source: http://news.yahoo.com/internet-sales-tax-bill-advances-senate-171508542.html

Linda McMahon Voting Results 2012 pbs ron paul Cnn Electoral Map roseanne barr guy fawkes

Drug therapy offers high cure rate for 2 hepatitis C subtypes

Apr. 23, 2013 ? A new drug is offering dramatic cure rates for hepatitis C patients with two subtypes of the infection -- genotype 2 and 3, say a team of scientists led by Weill Cornell Medical College researchers. These two subtypes account for approximately 25 percent of hepatitis C infection in the United States.

The drug, called sofosbuvir, offers more effective treatment for most patients studied in a Phase 3 clinical trial who had no other treatment options, report researchers in The New England Journal of Medicine. After three months of combined therapy with sofosbuvir and the antiviral drug ribavirin, the patient response rate for those with genotype 2 was 93 percent, and 61 percent in patients with genotype 3.

This new study is one of several testing new hepatitis C drugs that were published April 23 in an online edition of NEJM. The journal publication coincides with the International Liver Congress 2013 in Amsterdam, the Netherlands, where the results also will be presented.

"The new sofosbuvir therapy offers a much-needed alternative to standard therapy with interferon, which can cause significant side effects for hepatitis C patients," says the study's lead investigator, Dr. Ira Jacobson, chief of the Division of Gastroenterology and Hepatology and Vincent Astor Distinguished Professor of Medicine at Weill Cornell Medical College.

"We have dreamed for years of being able to eliminate interferon from our hepatitis C regimens and this study is one of several that are finally bringing us very close to realizing that goal," says Dr. Jacobson, who is also a gastroenterologist at the Center for Advanced Digestive Care at New York-Presbyterian Hospital/Weill Cornell Medical Center and medical director of the Center for the Study of Hepatitis C, a collaboration between Weill Cornell, NewYork-Presbyterian/Weill Cornell and The Rockefeller University.

The 207 patients enrolled in the clinical trial, known as POSITRON, either did not respond to interferon, could not tolerate it or were unwilling to use it, despite the fact that there were no other treatment options available to them.

"This new treatment represents a paradigm shift in the way that hepatitis C is going to be treated," says Dr. Jacobson. "We are achieving the same or higher cure rates in many patients with sofosbuvir, compared to interferon, and we are doing it in half the time with a drug that has a remarkable safety profile."

Dr. Jacobson estimates that up to half of patients with hepatitis C infection either can't use interferon or don't want to use it. "Sofosbuvir is an extremely promising treatment for this population. It is widely hoped that combinations of potent antiviral drugs will eventually replace the use of interferon, in general, for most hepatitis C patients."

The drug sofosbuvir works by interfering with the ability of the hepatitis C virus to replicate. The drug also confers a high barrier to developing the complication of drug resistance. The U.S. Food and Drug Administration (FDA) has not yet approved sofosbuvir. However, results of the four clinical trials published in the NEJM were used to support the regulatory filing submitted to the FDA by the drug's developer, Gilead Sciences, Inc.

No Treatment Options for Many Patients

Approximately 170 million people are infected with hepatitis C worldwide and 350,000 people die each year from the disease. According to federal statistics, there are an estimated four million people in the U.S. infected with hepatitis C. As there are often no symptoms, most people with hepatitis C are unaware that they are infected.

When left untreated, hepatitis C virus can cause progressive liver disease such as cirrhosis, liver cancer and liver failure. The virus is spread by contact with infected blood, such as through blood transfusions, injection drug use or sexual contact.

There are seven major genotypes of hepatitis C, but most cases are 1, 2 or 3. Genotype 1 is the most common subtype in the U.S. Genotypes 2 and 3 are more common in Europe than in the U.S. and genotype 3 is very prevalent on the Indian subcontinent.

In the study, three-fourths of participants (207) were randomized to treatment with sofosbuvir and ribavirin while one-fourth (71) of participants were randomized to a placebo treatment. All of the patients either did not respond to interferon, or did not want to use it. "This mirrors what happens frequently in the clinic," says Dr. Jacobson. "Between 15 and 30 percent of patients with hepatitis C genotype 2 or 3 infections do not have a response to interferon therapy and do not have alternate treatment options."

Patients were enrolled internationally at 63 sites in the United States, Canada, Australia and New Zealand.

Study results show the response rate for all treated patients with sofosbuvir was 78 percent compared to 0 percent in participants treated with placebo agents. Patients with genotype 2 had a higher cure rate (93 percent) than those with genotype 3 (61 percent), and patients without cirrhosis had a higher response rate (81 percent) compared with participants diagnosed with cirrhosis (61 percent).

The results of another clinical trial, led by Dr. David R. Nelson of the University of Florida at Gainesville, were incorporated into this NEJM manuscript publication. This clinical trial study, called FUSION, was designed to test sofosbuvir and ribavirin in hepatitis C patients with genotype 2 or 3 who had failed interferon therapy.

In FUSION, the drug regimen was tested for both 12 and 16 weeks in patients with genotype 2 or 3. The findings showed that extended use of sofosbuvir resulted in a higher cure rate in both genotypes, but that the difference seen in genotype 3 was highly significant. For genotype 2, 12 versus 16 weeks of treatment resulted in response rates of 86 percent compared to 94 percent; and for genotype 3, the response rates were 30 percent versus 62 percent, respectively.

"Given the absence to date of alternative therapies for patients with genotype 2 or 3 who have failed interferon therapy or for whom it is not an option, treatment with the new sofosbuvir regimen offers a vast improvement," Dr. Jacobson says. "But the optimal duration of treatment for genotype 3 patients, in order to maximize their chance of cure, remains undefined. It could be longer than 16 weeks." Dr. Jacobson adds that future clinical studies will continue to define the optimal length of treatment duration for patients with genotype 3, and that other antiviral drugs in combination with sofosbuvir might shorten the duration of treatment needed to maximize the rates of response.

Both the POSITRON and FUSION studies were funded by Gilead Sciences. Another paper in the same edition of the NEJM reports two additional studies of sofosbuvir-containing therapy, one evaluating a 12 week regimen of peginterferon, ribavirin and sofosbuvir in patients with genotypes 1, 4, 5 and 6 who have never been treated before; the other reporting results of a trial comparing 24 weeks of peginterferon and ribavin with 12 weeks of sofosbuvir and ribavirin in treatment na?ve patients with genotypes 2 and 3.

Dr. Jacobson is a consultant, lecturer and a funded research investigator for Gilead Sciences.

Share this story on Facebook, Twitter, and Google:

Other social bookmarking and sharing tools:


Story Source:

The above story is reprinted from materials provided by Weill Cornell Medical College.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Ira M. Jacobson, Stuart C. Gordon, Kris V. Kowdley, Eric M. Yoshida, Maribel Rodriguez-Torres, Mark S. Sulkowski, Mitchell L. Shiffman, Eric Lawitz, Gregory Everson, Michael Bennett, Eugene Schiff, M. Tarek Al-Assi, G. Mani Subramanian, Di An, Ming Lin, John McNally, Diana Brainard, William T. Symonds, John G. McHutchison, Keyur Patel, Jordan Feld, Stephen Pianko, David R. Nelson. Sofosbuvir for Hepatitis C Genotype 2 or 3 in Patients without Treatment Options. New England Journal of Medicine, 2013; : 130423030016000 DOI: 10.1056/NEJMoa1214854

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/HlNlHXEjxRY/130424103134.htm

pinterest attwireless taylor swift zac efron the scream stephen colbert new madrid fault rihanna and chris brown

Thursday, April 25, 2013

Death toll rises in Bangladesh building collapse

SAVAR, Bangladesh (AP) ? Workers trapped in the wreckage of a collapsed factory building in Bangladesh cried out for help Thursday, as rescuers struggled to reach survivors of a disaster that killed at least 149 people and reignited questions about the often lethal conditions the counrty's garment industry.

Army Brig. Gen. Mohammed Siddiqul Alam Shikder said many people are still trapped in the building, which housed a number of garment factories employing hundreds of people when it came tumbling down Wednesday morning. A clearer picture of the rescue operation would be available by afternoon, he said.

The disaster came less than five months after a factory fire killed 112 people and underscored the unsafe conditions faced by Bangladesh's garment workers, who produce clothes for global brands worn around the world. Workers said they had hesitated to enter the building on Wednesday morning because it had developed such large cracks a day earlier that it even drew the attention of local news channels. Just hours later it came tumbling down.

Searchers worked through the night to cut holes in the jumbled mess of concrete with drills or their bare hands, passing water and flashlights to those pinned inside the building.

"I gave them whistles, water, torchlights. I heard them cry. We can't leave them behind this way," said fire official Abul Khayer.

Abdur Rahim, who worked on the fifth floor, said a factory manager gave assurances that the cracks in the building were no cause for concern, so employees went inside.

"After about an hour or so, the building collapsed suddenly," Rahim said. He next remembered regaining consciousness outside.

On a visit to the site, Home Minister Muhiuddin Khan Alamgir told reporters the building had violated construction codes and "the culprits would be punished."

Abdul Halim, an official with the engineering department in the Dhaka suburb of Savar, said the owner was originally allowed to construct a five-story building but he added another three stories illegally.

Local police chief Mohammaed Asaduzzaman said police and the government's Capital Development Authority have filed separate cases of negligence against the building owner.

Habibur Rahman, police superintendent of Dhaka district, identified the owner as Mohammed Sohel Rana, a local leader of ruling Awami League's youth front. Rahman said police were also looking for the owners of the garment factories.

Among the textile businesses in the building were Phantom Apparels Ltd., New Wave Style Ltd., New Wave Bottoms Ltd. and New Wave Brothers Ltd., which make clothing for major brands including The Children's Place, Dress Barn, and Primark.

Jane Singer, a spokeswoman for The Children's Place, said that "while one of the garment factories located in the building complex has produced apparel for The Children's Place, none of our product was in production at the time of this accident."

"Our deepest sympathies go out to the victims of this terrible tragedy and their families," Singer said in a statement.

Dress Barn said that to its knowledge, it had "not purchased any clothing from that facility since 2010. We work with suppliers around the world to manufacture our clothing, and have a supply chain transparency program to protect the rights of workers and their safety."

Primark, a major British clothing retailer, confirmed that one of the suppliers it uses to produce some of its goods was located on the second floor of the building.

In a statement emailed to The Associated Press, Primark said it was "shocked and deeply saddened by the appalling incident." It added that it has been working with other retailers to review the country's approach to factory standards and will now push for this review to include building integrity.

Meanwhile, Primark's ethical trade team is working to collect information, assess which communities the workers come from, and to provide support "where possible."

John Howe, Cato's chief financial officer and executive vice president, told The Associated Press that it didn't contract with any of the factories directly but it's currently investigating what its "ties" were.

Howe said that one of Cato's domestic importers could have used one of the factories to fulfill some of the orders the retailer had placed. It's expected to have more information by Thursday.

Spanish retailer Mango denied reports it was using any of the suppliers in the building. However, in an email statement to the AP, it said that there had been conversations with one of them to produce a batch of test products.

Kevin Gardner, a spokesman at Wal-Mart Stores, Inc., the second-largest clothing producer in Bangladesh, said the company is investigating to see if a factory in the building was currently producing for the chain.

"We remain committed and are actively engaged in promoting stronger safety measures, and that work continues," Gardner added.

Workers said they didn't know what specific clothing brands were being produced in the building because labels are attached after the products are finished.

Charles Kernaghan, executive director of the Institute for Global Labour and Human Rights, which has an office in nearby Dhaka, says his staff is investigating the situation. He's hoping his team, working with local workers' groups, will be able to find out which brands were having their products made at the time of the collapse.

"You can't trust many buildings in Bangladesh," Kernaghan said. "It's so corrupt that you can buy off anybody and there won't be any retribution."

Sumi, a 25-year-old worker who goes by one name, said she was sewing jeans on the fifth floor with at least 400 others when the building fell.

"It collapsed all of a sudden," she said. "No shaking, no indication. It just collapsed on us."

She said she managed to reach a hole in the building where rescuers pulled her out.

Tens of thousands of people gathered at the site, weeping and searching for family members. Firefighters and soldiers with drilling machines and cranes worked with volunteers to search for survivors.

An enormous section of the concrete structure appeared to have splintered like twigs. Colorful sheets of fabric were tied to upper floors so those inside could climb or slide down and escape.

Rescuers carried the body of a young boy from the building, but it was not immediately clear what he had been doing inside. The building housed a bank and various shops in addition to the garment factories.

An arm jutted out of one section of the rubble. A lifeless woman covered in dust could be seen in another.

Rahim said his mother and father, who worked with him in the factory, were trapped inside.

Mosammat Khurshida wailed as she looked for her husband. "He came to work in the morning. I can't find him," she said. "I don't know where he is. He does not pick up his phone."

The morgue of the medical college echoed with the sobs of people waiting for the bodies of their loved ones. "Where's my mother? Where's my mother? Tell me, tell me, oh Allah, oh Allah!" Rana Ahmed cried.

Asaduzzaman, the local police chief, said nearly 100 bodies had been handed to their families as of Thursday morning.

The November fire at the Tazreen garment factory drew international attention to working conditions in Bangladesh's $20 billion-a-year textile industry. The country has about 4,000 garment factories and exports clothes to leading Western retailers. The industry wields vast power in the South Asian nation.

Tazreen lacked emergency exits, and its owner said only three floors of the eight-story building were legally built. Surviving employees said gates had been locked and managers had told them to go back to work after the fire alarm went off.

___

AP Retail Writer Anne D'Innocenzio in New York contributed to this report.

Source: http://news.yahoo.com/factory-building-collapse-bangladesh-kills-149-013225352--finance.html

nba trade deadline diane lane drew peterson Argo bonnaroo robin roberts Ashley Morrison

Wednesday, April 24, 2013

Obama hosts female senators for White House dinner

WASHINGTON (AP) ? Dining on Alaskan halibut and slices of peach pie, President Barack Obama hosted the women of the Senate at the White House on Tuesday, laying the groundwork for better relations with lawmakers from both parties.

All 20 female senators ? 16 Democrats, four Republicans ? showed up for the dinner, the White House said. The closed-door dinner last about two hours.

Senators departed the White House quietly after the dinner, and aides offered few details about what was discussed, citing a longstanding rule that applies to the female senators' quarterly dinners: What happens at dinner stays at dinner.

But the White House said that Obama and the senators discussed budget issues, job creation and immigration reform as well as ways to reduce gun violence and expand educational opportunities for children. The president told his guests that he remained committed to ensuring that all resources remain available as the investigation continues into the Boston Marathon bombings, the White House said.

Obama's dinner with the Senate's female caucus followed a series of similar meetings he's held with lawmakers of both genders aimed at strengthening the lines of communication with Congress and improving prospects for compromise on second-term priorities like an immigration overhaul and a budget deal. Last week, Obama shared a meal with a dozen Senate Democrats at a hotel near the White House. He's hosted two similar dinners for Senate Republicans in recent weeks.

Sen. Kirsten Gillibrand, a Democrat from New York, said she suggested the meeting while traveling with Obama late last year to view hurricane damage.

"I said as you put together your agenda for this term, if you want a bipartisan, core group of people to start moving legislation, a great way to start is the women senators," Gillibrand said in an interview shortly before the dinner.

Gillibrand suggested Obama join one of the women's regularly scheduled dinners, but he one-upped them, offering to host them at the White House instead.

She said economic issues of importance to women would be on the agenda, such as equal pay, a higher minimum wage and Obama's proposal to expand access to preschool.

"The president always says if you want to out-innovate, out-educate, out-compete the competition, you're only going to do it with women leading the way," Gillibrand said.

Among the lawmakers who joined Obama for dinner were Sens. Heidi Heitkamp, D-N.D., Deb Fischer, R-Neb., and Kelly Ayotte, R-N.H., all of whom voted this month against the expanded background checks that Obama had pushed for as the central element of his proposals to reduce gun violence.

Source: http://news.yahoo.com/obama-hosts-female-senators-white-house-dinner-224923046--politics.html

jadeveon clowney orange bowl Rose Parade 2013 rex ryan PNC Bank Louisville football Fidelity

Heat take off late, top Bucks 98-86 for 2-0 lead

Miami Heat guard Dwyane Wade, left, and forward LeBron James laugh as they sit on the bench in the final seconds of Game 2 in their first-round NBA basketball playoff series against the Milwaukee Bucks, Tuesday, April 23, 2013 in Miami. Wade scored 21 points and James contributed 19 as the Heat won 98-86. (AP Photo/Wilfredo Lee)

Miami Heat guard Dwyane Wade, left, and forward LeBron James laugh as they sit on the bench in the final seconds of Game 2 in their first-round NBA basketball playoff series against the Milwaukee Bucks, Tuesday, April 23, 2013 in Miami. Wade scored 21 points and James contributed 19 as the Heat won 98-86. (AP Photo/Wilfredo Lee)

Miami Heat forward LeBron James (6) shoots against Milwaukee Bucks forward John Henson (31) during the first half of Game 2 in their first-round NBA basketball playoff series, Tuesday, April 23, 2013 in Miami. (AP Photo/Wilfredo Lee)

Miami Heat guard Ray Allen shoots against Milwaukee Bucks guard J.J. Redick (5) during the first half of Game 2 in their first-round NBA basketball playoff series, Tuesday, April 23, 2013 in Miami. (AP Photo/Wilfredo Lee)

Milwaukee Bucks forward John Henson, left, fouls Miami Heat forward Shane Battier (31) as he goes up for a shot during the first half of Game 2 in their first-round NBA basketball playoff series, Tuesday, April 23, 2013 in Miami. (AP Photo/Wilfredo Lee)

(AP) ? Everyone in the Miami huddle was bracing for a grind to the finish. On the other end, the sense around the Milwaukee bench was that an upset was there for the taking.

Then the Heat landed a swift knockout punch.

Dwyane Wade scored 21 points, LeBron James finished with 19 and the Heat used a frantic start to the fourth quarter to pull away and beat the Bucks 98-86 in Game 2 of the teams' Eastern Conference first-round series on Tuesday night.

It was 68-65 entering the fourth. With James and four backups on the court, the Heat needed only 2 minutes, 22 seconds to outscore Milwaukee 12-0 and stretch the lead to 80-65 ? ensuring the reigning NBA champions would take a 2-0 series lead into Game 3 on Thursday night.

"We held court," Heat coach Erik Spoelstra said. "We protected it for two games. We did what we're supposed to do. And that's it."

Chris Bosh, Shane Battier and Chris Andersen all scored 10 points for the Heat. James' postseason streaks of 22 straight games with at least 20 points, and 16 straight games of at least 25 points, both came to an end.

Ultimately, none of that mattered.

"We didn't get into our game like we wanted to in that third quarter," James said. "But we went into the fourth with a (three-point) lead and we were able to jump on them."

Ersan Ilyasova scored 21 points for Milwaukee, which got 16 from Mike Dunleavy and 14 from Larry Sanders. The Bucks' starting guards, Brandon Jennings and Monta Ellis, combined for only 15 points ? after teaming up to score 48 in Game 1.

"It's a series," said Sanders, who had a sore right ankle after he collided with Battier in the fourth quarter. "We made progress this game."

They'll need to make more, and do it quickly. James has never lost in 10 previous series where his team takes a 2-0 lead, and Wade is 8-0 in that same situation.

"In the playoffs you've got to find different ways to win," Wade said. "No matter what everybody says on the outside, (Milwaukee) is a good team. They played us very well."

For about 46 minutes, the Bucks played them even.

It was that 12-0 run that was the difference ? in what finished as a 12-point game.

Andersen started it with a three-point play, James had a layup not long afterward and the Heat were starting to roll. Another basket by Andersen off a pass from Ray Allen made it 77-65, and James found Norris Cole for a 3-pointer that capped the flurry and made it 80-65.

Just like that, it was over, even to Miami's surprise.

"They were doing some things that had us spinning around a little bit defensively, got us on our heels, and offensively we never got into a rhythm," Spoelstra said. "So we figured we were just going to have to find a way to grind in the fourth quarter, figuring it was going to be a close game."

The Heat have raved about their depth all season, so they had no qualms about sending James out to start the fourth with Cole, Andersen, Battier and Ray Allen.

By the time starters like Wade and Bosh got back onto the court, the task was merely protecting the lead, which the Heat did with relative ease.

"We felt pretty good about the position we were in, giving ourselves an opportunity on the road with 12 minutes to go," Bucks coach Jim Boylan said. "You feel good about that. Then they come out, go on a 12-0 run and it changes the complexion of the game. Playing catch-up is very hard to do against a high-quality team like Miami."

Jennings and Ellis combined for 48 points in Game 1, and the Bucks got blown out. So in the first half of Game 2, they combined for one point, were held to five shots that all missed ... and the Bucks were within 47-43 at halftime.

Chances are, very few would have seen that coming.

But play was sloppy from the outset, with the teams combining for eight turnovers in the first 6 minutes to set the tone for a clumsy first half. Wade, James and Chalmers shot 15 for 19 combined in the first half for Miami ? and the rest of the Heat were 3 for 17. For Milwaukee, Ilyasova had 12 points in the first 10 minutes, then two points the rest of the half.

So much like in Game 1, Milwaukee came out for the second half with a chance of stealing home-court advantage.

And for the entirety of the third quarter, the Bucks hung around, though the Heat showed some signs of getting things going. Bosh had a dunk for a six-point lead, then made a jumper ? on a play that James started by running down a loose ball and flicking it between his legs for a save along the sideline ? for a 68-60 lead, what was then the biggest Heat margin of the night.

The Bucks got within 68-65 to end the third, but then came the run that Miami had been waiting for all evening.

Jennings said Milwaukee would win in six games before the series began, and his confidence didn't waver even now with his club in an 0-2 hole.

"We showed a lot of improvement tonight," said Jennings, who shot 3 for 15. "Aside of making that run in the fourth I think we should have won this game."

Both teams got a big scare with 6:59 left. Battier drove for a layup from the right wing, and Sanders rushed down the middle of the lane to attempt a block. A collision ensued and both players hit the court awkwardly, Battier hitting his head on the hardwood and Sanders ? who fell over Battier ? grabbing at his right leg.

Battier made two free throws, then departed for the Heat locker room to get stitches on his chin.

NOTES: It's the 11th time the Heat have gone up 2-0 in a playoff series. They're 10-0 in the previous instances. ... Milwaukee has lost 21 of its last 29 playoff games. ... Sanders was third in the NBA's Most Improved Player voting, behind Indiana's Paul George and New Orleans' Greivis Vasquez. "Look where he was last year and where he is today. The improvement is very obvious," said Boylan, who thought Sanders should have won. ... Jennings was held without a first-half basket for only the fifth time all season.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2013-04-23-BKN-Bucks-Heat/id-a8ee6445642148808130b0e3f3a6915e

petrino fired george zimmerman charged big sean sherri shepherd sherri shepherd arkansas razorbacks trisomy 18

AppShopper Social uses your friends to find apps for you

AppShopper Social uses your friends to find apps for you

App discovery service AppShopper has reappeared on the App Store after being removed last year, and their new app, AppShopper Social, relies heavily on social features to help users find apps. After creating your AppShopper account, you can populate the Friends list either by manually adding friends or adding your Twitter account. When you've added some friends, the Stream will be populated with the apps that they have as well as those in their wish list.

Just like the old app, you can add apps you already own to a list, so they won't be suggested to you, as well as add apps you want to your wish list. With the new social features, you can rate the apps you have, and when people who have added you as a friend view the app, they will see your rating. When viewing the stream, the ratings of your friends will appear as blue stars, as opposed to the black stars that indicate App Store ratings.

One feature that is missing in the initial release of AppShopper Social is the ability to look at your friends individually to see the apps that they have added to their lists, though AppShopper has said that this feature is on its way.

AppShopper Social is a completely new app for iPhone, and is available for free on the App Store. If you pick this one up, let us know what you think!

Source: AppShopper blog

    


Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/d46IKSGII5o/story01.htm

tagged Heptathlon London 2012 shot put London 2012 Track And Field Jordyn Wieber michael phelps Kerri Strug

Sainsbury shows strongest growth of UK's "big four" - Kantar

LONDON (Reuters) - J Sainsbury delivered the strongest growth among Britain's so-called Big Four grocers in the 12 weeks to April 14 and was the only one to increase market share, monthly industry data showed on Tuesday.

Market researcher Kantar Worldpanel said sales at Sainsbury, Britain's third-largest grocer, grew 5.4 percent in the period, increasing its market share to 16.9 percent.

Kantar said a feature of the period was an increasingly polarised grocery market, with the upmarket Waitrose, which is owned by John Lewis, as well as discounters Aldi and Lidl, all posting record market shares of 4.9 percent, 3.4 percent and 3.0 percent respectively.

"Pressure on household budgets is undoubtedly driving some of the growth at the discounters, but messages about quality are starting to resonate," said Edward Garner, director at Kantar Worldpanel.

"Shoppers rate Waitrose highly in terms of provenance and clearly-defined supply chains - important credentials in the wake of the horsemeat scandal and factors which have clearly boosted sales at the retailer," Garner added.

Sales at market leader Tesco rose 1.0 percent and were up 3.0 percent at No. 2 player Asda, the British arm of Wal-Mart, while sales increased 0.3 percent at No. 4 grocer Wm Morrison Supermarkets - outcomes all below overall market growth of 3.6 percent.

Last month Sainsbury posted higher-than-expected fourth-quarter sales, while last week Tesco announced a 51.5 percent slump in yearly profit.

Kantar said grocery inflation was 3.8 percent for the 12 week period.

(Reporting by James Davey; Editing by David Holmes)

Source: http://news.yahoo.com/sainsbury-shows-strongest-growth-uks-big-four-kantar-113618819--finance.html

Fathers Day Quotes Stevie J mothers day 2012 cinco de mayo osama bin laden death spinal muscular atrophy brooklyn nets

will.i.am, Video Justin Bieber Perform New Song on Dancing with the Stars Results Show

Source:

madonna super bowl performance madonna half time m.i.a super bowl coin toss best superbowl commercials madonna super bowl halftime kelly clarkson super bowl

slaw leonora: samsung galaxy mini manual: Municipalities to Trebon ...


First - 31st August daily except Mondays, 9 to 17 h Blatsk? Museum download calculator of the spiritual landscape of South Bohemia - exhibition brings small church download calculator architecture scattered throughout the countryside of South Bohemia. On display are also impressive artistic images Jind?ich?v photographer George Tiller.
5th August, 17 hours Park for cultural house ADVENTURE Bumblebee Brundibar - the fairy tale Fridays for cultural house. In case of inclement weather, performances take place in the community center.
13th - 14th August ??pec ??PECK? pilgrimage - in Saturday, 8.13 10 h football tournament, from 20 h dance (Wohryzek Band) on Sunday, 14.08 from 14 h Fire Competition Mayor's Cup, from 15 h dance (Mini ?ev?t?nka)
20th August, 11 hours football pitch Horusice Horusick? fairground FESTIVAL - 11 h football tournament, evening play for listening and dancing Old.times.band. During the day, children's download calculator games, a display of fire-fighting equipment, lots of fun.
End of excerpt Article on VESELSK? Calendar of Events - August 2011 id: 24472, Category: Culture and Sport, Category: Archive of cultural events, Published: 27.07.11, dislikes Marie Ko?inov?, Share on Facebook Related Articles Jo?ka ?muka? Trebon Truckshow Lu?nice 2012 cultural mosaic - monastery Borovany download calculator 2012 Farmers Markets 2012 Grand Prix Trebon Trebon fire attack Cultural download calculator and sporting events in 2012 - HAPPY above the river Invitation Lomnica above the river on the events of 2012
Menu of cultural events Archive cultural events Traditional events Anifilm Summer in Trebon Trebon area Fishing Festival T?ebo?sk? Nocturna T?ebo?sk? Theatre Festival Theatre and concerts Galleries and Exhibitions Permanent Exhibitions Cinema Sport and Recreation Bowling Sports Hall Squash Tennis Photos download calculator Videos E-shop
Recent download calculator comments download calculator Libor Uher (Akvatrhy akvaritn?ch fish, plants, accessories and protection of animals) Dana (Action 2013 Vinot?ky Radka and Meadows at Golden Canal) Carolina (Rosenberg pond) Jan (T?ebo?sk? Beer Festival 2013) Proch?zkov? (Pond World) Peter (Old Clay - part of the village Trebon)
Latest Articles download calculator Concerto for hospice Trebon week for the first hospice Suchdol download calculator vej?lap 2013 Kino Suchdol n Lu?nic? - May 2013 Cottage Vlachnovice T?ebo?sk? Shakespeare Theatre Festival 2013: Night at the time of the solstice - TDF 2013
Anifilm
Municipalities to Trebon: Trebon | Borovany | Chlum Trebon | Domanin | Lomnica above the river | Lu?nice | Majdalena | Novosedly over Ne??rkou | Pon?dr??ka | Stankov | Straz nad Ne??rkou | St??b?ec | Suchdol above the river | Vlkov above the river |
Most are looking download calculator for: pool | River Lu?nice | Schwarzenberg Tomb | apartments Trebon | Cinema download calculator | T?ebo?sko | accommodation | Christmas carp | Accommodation in Trebon | hotel Trebon | cycling | cycling Trebonsko | City Council | Spa | Theater JK Tyl
Trebonsko.cz - operator Destinations Trebonsko download calculator ops | RSS | Site Map | Web Design and SEO by ODEON Partners Destinations Trebonsko ops: Fisheries Trebon HLD as | FISH MARKET as | Cottages by DDS TOUR sro

Source: http://samsunggalaxymiual.blogspot.com/2013/04/municipalities-to-trebon-trebon.html

sessions march madness scores doonesbury padma lakshmi daughtry lakers trade ann arbor news

Source: http://slaw-leonora.blogspot.com/2013/04/samsung-galaxy-mini-manual.html

Bram Stoker books Paula Broadwell Photos Veterans Day 2012 Nate Silver stock market stock market Obama Acceptance Speech 2012

Saturday, April 20, 2013

Canada urges G20 to set hard targets for debt reduction

').append($('#scplatformSocialToolBarMain').contents().clone()));$('.stb-boxstyle-l, .stb-boxstyle-r').append($('#scplatformSocialToolbarBox').contents().clone()).addClass('stb-boxstyle');jQuery.async('scp', function(){$.scp.async('\x2f\x2fmedia-social.s-msn.com\x2fs\x2fjs\x2f18.43\x2fue.min.js', function(){$('\x23pvtbtop').not('.stb-boxstyle-l, .stb-boxstyle-r').not($('\x23pvtbtop').next('div.stb-minitb').prev()).after($('').append($('#scplatformSocialToolBarMain').contents().clone()));$('.stb-boxstyle-l, .stb-boxstyle-r').not('.stb-boxstyle').append($('#scplatformSocialToolbarBox').contents().clone()).addClass('stb-boxstyle');});jQuery.scp.socialToolbar({"jsUrl":"//media-social.s-msn.com/s/js/18.43/ue.min.js","shareCountUrlBase":"//us.social.msn.com/boards","ajaxStubBaseUri":"http://socialcf.blu.msn.com/","responseBridgeUrl":"http://money.ca.msn.com/responsebridge.min.htm","locale":"en-ca","strings":{"lc_shrbtntooltipformatsingular":"Shared {0} time","lc_shrbtntooltipformatplurar":"Shared {0} times","lc_shrintro":"I thought you would be interested in this: {0}","lc_defml":"Email program","lc_hotml":"Hotmail","lc_gml":"Gmail","lc_yml":"Yahoo! Mail","lc_prt":"Print","lc_rdcmnts":"Read comments","lc_eml":"Email","lc_shr":"Share","lc_numfmt":"{0}","lc_numfmt_thousands":"{0}k","lc_numfmt_millions":"{0}M","lc_numfmt_billions_plus":"{0}B+","lc_share_with_friends":"Share with Friends","lc_thanks_for_sharing":"Your story has been shared.","lc_thanks_for_sharing_message":"Now, like us on Facebook.","lc_already_like":"Already like us?","lc_dont_show_again":"Don\u0027t show this again.","lc_shrf":"Share","lc_close":"close","lc_tooltip_close":"Close"},"sharingSites":[{"id":"2","name":"Facebook","icon":"//media-social.s-msn.com/images/blogs/Facebook.png","smallIcon":"//media-social.s-msn.com/images/blogs/Facebook-s.png","urlTemplate":"https://www.facebook.com/dialog/feed?app_id=%7Bfb_appid%7D\u0026link=%7Burl%7D\u0026picture=%7Bimage%7D\u0026name=%7Btitle%7D\u0026description=%7Bdesc%7D\u0026redirect_uri=%7Bredir%7D\u0026caption=%7Burl%7D"},{"id":"50","name":"Twitter","icon":"//media-social.s-msn.com/images/blogs/Twitter3.png","smallIcon":"//media-social.s-msn.com/images/blogs/Twitter3-s.png","urlTemplate":"https://twitter.com/share?url=%7Bs-url%7D\u0026text=%7Btitle%7D\u0026via=%7Btwittervia%7D\u0026related=%7Btwitterfollow%7D"},{"id":"6","name":"LinkedIn","icon":"//media-social.s-msn.com/images/blogs/linkedin.png","smallIcon":"//media-social.s-msn.com/images/blogs/linkedin-s.png","urlTemplate":"http://www.linkedin.com/shareArticle?mini=true\u0026url=%7Burl%7D\u0026title=%7Btitle%7D"},{"id":"9","name":"Stumbleupon","icon":"//media-social.s-msn.com/images/blogs/stumbleupon2.png","smallIcon":"//media-social.s-msn.com/images/blogs/stumbleupon2-s.png","urlTemplate":"http://www.stumbleupon.com/submit?url=%7Burl%7D\u0026title=%7Btitle%7D"},{"id":"12","name":"Reddit","icon":"//media-social.s-msn.com/images/blogs/reddit.png","smallIcon":"//media-social.s-msn.com/images/blogs/reddit-s.png","urlTemplate":"http://reddit.com/submit?url=%7Bs-url%7D\u0026title=%7Btitle%7D"},{"id":"19","name":"Newsvine","icon":"//media-social.s-msn.com/images/blogs/newsvine.png","smallIcon":"//media-social.s-msn.com/images/blogs/newsvine-s.png","urlTemplate":"http://www.newsvine.com/_tools/seed\u0026save?popoff=0\u0026u=%7Bs-url%7D\u0026h=%7Btitle%7D"},{"id":"10","name":"Delicious","icon":"//media-social.s-msn.com/images/blogs/delicious.png","smallIcon":"//media-social.s-msn.com/images/blogs/delicious-s.png","urlTemplate":"http://www.delicious.com/save?v=5\u0026noui\u0026jump=close\u0026url=%7Burl%7D\u0026title=%7Btitle%7D"},{"id":"22","name":"Orkut","icon":"//media-social.s-msn.com/images/blogs/orkut.png","smallIcon":"//media-social.s-msn.com/images/blogs/orkut-s.png","urlTemplate":"http://promote.orkut.com/preview?nt=orkut.com\u0026tt=%7Btitle%7D\u0026du=%7Bs-url%7D\u0026cn=%7Bdesc%7D\u0026tn=%7Bimage%7D"},{"id":"27","name":"Blogger","icon":"//media-social.s-msn.com/images/blogs/blogger.png","smallIcon":"//media-social.s-msn.com/images/blogs/blogger-s.png","urlTemplate":"http://www.blogger.com/blog_this.pyra?n=%7Btitle%7D\u0026u=%7Bs-url%7D"},{"id":"42","name":"Tumblr","icon":"//media-social.s-msn.com/images/blogs/tumblr.png","smallIcon":"//media-social.s-msn.com/images/blogs/tumblr-s.png","urlTemplate":"http://www.tumblr.com/share/link?url=%7Bs-url%7D\u0026name=%7Btitle%7D\u0026description=%7Bdesc%7D"}],"fbLocale":"en_US","fbLocaleWidthLike":90,"fbLocaleWidthRecommend":130,"fbBoxStyleLocaleWidthLike":55,"fbBoxStyleLocaleWidthRecommend":95,"fbLocaleWidthShare":115,"fbShare":true,"fbFanPage":null,"twLocale":"en","twLocaleWidth":110,"twLocaleWidthNoBubble":58,"gLocale":"en","msnShareLocaleWidth":45,"fblkAppId":"132970837947","emailTitleTemplate":"{sitename}: {title}","emailBodyTemplate":"I thought you would be interested in this: {title} ({url})","ver":"","style":"higblue","gmt":"-5"});});$(document).ready(function () {if($.scpTrack){if($('\x23pvtbtop').not('.stb-boxstyle-l, .stb-boxstyle-r').length > 0){$.scpTrack.add('scpToolbarMini_V18.43');}if($('.stb-boxstyle-l, .stb-boxstyle-r').length > 0){$.scpTrack.add('scpToolbarBoxstyle_V18.43');}if($('div.stb2-ext').length > 0){$.scpTrack.add('scpToolbarExternal_V18.43');}if($('#scplatformSocialToolBarMain').not(':hidden').length > 0){$.scpTrack.add('scpToolbarMain_V18.43');}}});//]]>

Source: http://money.ca.msn.com/investing/news/breaking-news/canada-urges-g20-to-set-hard-targets-for-debt-reduction

andy williams Lady Gaga New Girl Avalanna Gigi Chao Jimmy Hoffa Ed Hochuli

This Is the World's Most Complicated Timepiece

Modern digital watches can be beautifully engineered and designed items, but they will always lack the craftsmanship that their mechanical predecessors possess. This hand-wound masterpiece, declared "the most complicated watch in the world" by its maker, doesn't do anything a digital watch couldn't replicate but it does so with soul. It also costs $5 million which makes for some very expensive soul. More »
    


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/qmevL9yBUEo/this-is-the-worlds-most-complicated-timepiece

Stephanie Bongiovi stanford football guy fieri Jill Kelley hope solo hope solo tesla model s

Monday, April 15, 2013

Vitamin D may reduce risk of uterine fibroids, according to NIH study

Vitamin D may reduce risk of uterine fibroids, according to NIH study [ Back to EurekAlert! ] Public release date: 15-Apr-2013
[ | E-mail | Share Share ]

Contact: Robin Mackar
rmackar@niehs.nih.gov
919-541-0073
NIH/National Institute of Environmental Health Sciences

Women who had sufficient amounts of vitamin D were 32 percent less likely to develop fibroids than women with insufficient vitamin D, according to a study from researchers at the National Institutes of Health.

Fibroids, also known as uterine leiomyomata, are noncancerous tumors of the uterus. Fibroids often result in pain and bleeding in premenopausal women, and are the leading cause of hysterectomy in the United States.

The study of 1,036 women, aged 35-49, living in the Washington, D.C., area from 1996 to 1999, was led by Donna Baird, Ph.D., a researcher at the National Institute of Environmental Health Sciences (NIEHS), part of NIH. Baird and her collaborators at The George Washington University and the Medical University of South Carolina screened participants for fibroids using ultrasound. They used blood samples to measure the primary circulating form of vitamin D, known as 25-hydroxy D. Those with more than 20 nanograms per milliliter of 25-hydroxy D were categorized as sufficient, though some experts think even higher levels may be required for good health. The body can make vitamin D when the skin is exposed to the sun, or vitamin D can come from food and supplements.

Study participants also completed a questionnaire on sun exposure. Those who reported spending more than one hour outside per day also had a decreased risk of fibroids. The estimated reduction was 40 percent. Although fewer black than white participants had sufficient 25-hydroxy D levels, the estimated reduction in prevalence of fibroids was about the same for both ethnic groups.

"It would be wonderful if something as simple and inexpensive as getting some natural sunshine on their skin each day could help women reduce their chance of getting fibroids," said Baird.

Baird also noted that, though the findings are consistent with laboratory studies, more studies in women are needed. Baird is currently conducting a study in Detroit to see if the findings from the Washington, D.C., study can be replicated. Other NIEHS in-house researchers, led by Darlene Dixon, D.V.M., Ph.D., are learning more about fibroid development, by examining tissue samples from study participants who had surgery for fibroids.

"This study adds to a growing body of literature showing the benefits of vitamin D," said Linda Birnbaum, Ph.D., director of NIEHS and the National Toxicology Program.

###

NIEHS supports research to understand the effects of the environment on human health and is part of NIH. For more information on environmental health topics, visit http://www.niehs.nih.gov. Subscribe to one or more of the NIEHS news lists to stay current on NIEHS news, press releases, grant opportunities, training, events, and publications.

About the National Institutes of Health (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit http://www.nih.gov.

NIH...Turning Discovery Into Health

Reference: Baird DD, Hill MC, Schectman JM, Hollis BW. 2013. Vitamin D and the risk of uterine fibroids. Epidemiology; 24(3):447-453.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Vitamin D may reduce risk of uterine fibroids, according to NIH study [ Back to EurekAlert! ] Public release date: 15-Apr-2013
[ | E-mail | Share Share ]

Contact: Robin Mackar
rmackar@niehs.nih.gov
919-541-0073
NIH/National Institute of Environmental Health Sciences

Women who had sufficient amounts of vitamin D were 32 percent less likely to develop fibroids than women with insufficient vitamin D, according to a study from researchers at the National Institutes of Health.

Fibroids, also known as uterine leiomyomata, are noncancerous tumors of the uterus. Fibroids often result in pain and bleeding in premenopausal women, and are the leading cause of hysterectomy in the United States.

The study of 1,036 women, aged 35-49, living in the Washington, D.C., area from 1996 to 1999, was led by Donna Baird, Ph.D., a researcher at the National Institute of Environmental Health Sciences (NIEHS), part of NIH. Baird and her collaborators at The George Washington University and the Medical University of South Carolina screened participants for fibroids using ultrasound. They used blood samples to measure the primary circulating form of vitamin D, known as 25-hydroxy D. Those with more than 20 nanograms per milliliter of 25-hydroxy D were categorized as sufficient, though some experts think even higher levels may be required for good health. The body can make vitamin D when the skin is exposed to the sun, or vitamin D can come from food and supplements.

Study participants also completed a questionnaire on sun exposure. Those who reported spending more than one hour outside per day also had a decreased risk of fibroids. The estimated reduction was 40 percent. Although fewer black than white participants had sufficient 25-hydroxy D levels, the estimated reduction in prevalence of fibroids was about the same for both ethnic groups.

"It would be wonderful if something as simple and inexpensive as getting some natural sunshine on their skin each day could help women reduce their chance of getting fibroids," said Baird.

Baird also noted that, though the findings are consistent with laboratory studies, more studies in women are needed. Baird is currently conducting a study in Detroit to see if the findings from the Washington, D.C., study can be replicated. Other NIEHS in-house researchers, led by Darlene Dixon, D.V.M., Ph.D., are learning more about fibroid development, by examining tissue samples from study participants who had surgery for fibroids.

"This study adds to a growing body of literature showing the benefits of vitamin D," said Linda Birnbaum, Ph.D., director of NIEHS and the National Toxicology Program.

###

NIEHS supports research to understand the effects of the environment on human health and is part of NIH. For more information on environmental health topics, visit http://www.niehs.nih.gov. Subscribe to one or more of the NIEHS news lists to stay current on NIEHS news, press releases, grant opportunities, training, events, and publications.

About the National Institutes of Health (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit http://www.nih.gov.

NIH...Turning Discovery Into Health

Reference: Baird DD, Hill MC, Schectman JM, Hollis BW. 2013. Vitamin D and the risk of uterine fibroids. Epidemiology; 24(3):447-453.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-04/nioe-vdm041513.php

Mars landing Gabby Douglas John Orozco Garrett Reid shawn johnson Tony Sly Lauren Perdue

Antarctic ice samples: What do they say about global warming?

Antarctic ice core samples, up to 150,000 years old, may help scientists estimate whether it will take 50 years - or 500 years - for the Ross Ice Shelf to collapse at the current rate of climate change.

By Nick Perry and Rod McGuirk,?Associated Press / April 6, 2013

Scientist Nancy Bertler holds the final section of ice she collected from a half-mile under Antarctica's surface in a laboratory freezer, near Wellington, New Zealand. Antarctica's pristine habitat provides a laboratory for scientists studying the effects of climate change.

(AP Photo/Nick Perry)

Enlarge

Nancy Bertler and her team took a freezer to the coldest place on Earth, endured weeks of primitive living and risked spending the winter in Antarctic darkness, to go get ice ? ice that records our climate's past and could point to its future.

Skip to next paragraph

' + google_ads[0].line2 + '
' + google_ads[0].line3 + '

'; } else if (google_ads.length > 1) { ad_unit += ''; } } document.getElementById("ad_unit").innerHTML += ad_unit; google_adnum += google_ads.length; return; } var google_adnum = 0; google_ad_client = "pub-6743622525202572"; google_ad_output = 'js'; google_max_num_ads = '1'; google_feedback = "on"; google_ad_type = "text"; google_adtest = "on"; google_image_size = '230x105'; google_skip = '0'; // -->

They drilled out hundreds of ice cores, each slightly longer and wider than a baseball bat, from the half-mile-thick ice covering Antarctica's Roosevelt Island. The cores, which may total 150,000 years of snowfall, almost didn't survive the boat ride to New Zealand because of a power outage.

Bertler hopes the material will help her estimate how long the Ross Ice Shelf would last under the current rate of climate change before falling apart.

Evidence from the last core her team hauled out needs further study, but it contains material that Bertler said appeared to be marine sediment that formed recently ? at least in geological terms measured in thousands of years.

That would bolster scientists' suspicions that the shelf could collapse again if global temperatures keep rising, triggering a chain of events that could raise sea levels around the world.

"From a scientific point of view, that's really exciting. From a personal point of view, that's really scary," said Bertler, a senior research fellow at the Antarctic Research Centre at the Victoria University of Wellington.

The ice shelf acts as a natural barrier protecting massive amounts of ice in West Antarctica, and that ice also could fall into the ocean if the shelf fell apart. Scientists say West Antarctica holds enough ice to raise sea levels by between 2 meters (6.5 feet) and 6 meters (20 feet) if significant parts of it were to collapse.

Ted Scambos, the lead scientist at the National Snow and Ice Data Center at the University of Colorado, said that even under the worst case scenario he thinks it would take at least 500 years for West Antarctica's ice to melt.

However, he said a discovery of sediment would indicate a significant portion of the ice shelf is under threat of becoming unstable again, and that the implications were "huge."

Bertler hopes the material she recovered will help her to estimate by the end of this year whether it will take 50 years or 500 years for the ice shelf to collapse at the current rate of climate change. Those answers should prove important for policymakers who, she said, may need to decide whether to build sea walls or move populations to higher ground.

Bertler's project is one of scores that take place on Antarctica every Southern Hemisphere summer. To scientists, the continent's pristine habitat offers a unique record of the planet's weather and a laboratory for studying the effects of climate change.

Studies indicate that while the Arctic has suffered what scientists consider to be alarming rates of ice loss in recent years, the Antarctic ice shelf has remained relatively stable despite having have lost ice in recent decades.

Research in Antarctica creates huge logistical and personal challenges.

Bertler's camp on Roosevelt Island is a three-hour flight from the nearest permanent Antarctic outposts, Scott Base and McMurdo Station. The island is surrounded by the Ross Ice Shelf, the world's largest mass of floating ice, covering an area the size of Spain.

Even during the spring and summer months when Bertler's team was working there, the temperature sometimes dropped to minus 25 C (minus 13 F) and there were frequent storms and thick fog.

Source: http://rss.csmonitor.com/~r/feeds/science/~3/x_6KmBRtxxI/Antarctic-ice-samples-What-do-they-say-about-global-warming

Jessica Lange NFL scores week 3 kat dennings Steve Sabol Yom Kippur 2012 Aaron Paul packers

Sunday, April 14, 2013

As U.S. talks up diplomacy, N. Korea takes hard line

TOKYO (AP) ? The United States and Japan opened the door Sunday to new nuclear talks with North Korea if the saber-rattling country lowered tensions and honored past agreements, even as it rejected South Korea's latest offer of dialogue as a "crafty trick."

U.S. Secretary of State John Kerry told reporters in Tokyo that North Korea would find "ready partners" in the United States if it began abandoning its nuclear program.

Japan's foreign minister, Fumio Kishida, also demanded a resolution to a dispute concerning Japanese citizens abducted decades ago by North Korean officials.

The diplomats seemed to point the way for a possible revival of the six-nation talks that have been suspended for four years.

China long pushed has for the process to resume without conditions. But the U.S. and allies South Korea and Japan fear rewarding North Korea for its belligerence and endless repetition of a cycle of tensions and failed talks that have prolonged the crisis.

Kerry's message of openness to diplomacy was clear, however unlikely the chances appeared that North Korean leader Kim Jong Un's government would meet the American's conditions.

"I'm not going to be so stuck in the mud that an opportunity to actually get something done is flagrantly wasted because of a kind of predetermined stubbornness," he told U.S.-based journalists.

"You have to keep your mind open. But fundamentally, the concept is they're going to have to show some kind of good faith here so we're not going to around and around in the same-old, same-old," he said.

Tensions have run high on the Korean Peninsula for months, with North Korea testing a nuclear device and its intercontinental ballistic missile technology.

The reclusive communist state hasn't stopped there. It has issued almost daily threats that have included possible nuclear strikes against the United States. Analysts and foreign officials say that is still beyond the North Koreans' capability.

While many threats have been dismissed as bluster, U.S. and South Korean say they believe the North in the coming days may test a mid-range missile designed to reach as far as Guam, the U.S. territory in the Pacific where the Pentagon is deploying a land-based missile-defense system.

Japan is the last stop on a 10-day trip overseas for Kerry, who visited Seoul and Beijing as well in recent days.

In South Korea, he strongly warned North Korea not to launch a missile and he reaffirmed U.S. defense of its allies in the region. In China, he secured a public pledge from Beijing, the lone government with significant influence over North Korea, to rid the North of nuclear weapons.

Before returning to the United States, Kerry planned a speech Monday in Japan on the Obama administration's Asia policy.

So far, Republican lawmakers in the U.S. have largely backed the administration's efforts on North Korea.

U.S. Sen. Marco Rubio, R-Fla., told CBS' "Face the Nation" that he was encouraged by Kerry's China visit and that he hoped "we can get the Chinese to care more about this issue.

U.S. Sen. John McCain of Arizona suggested on CNN's "State of the Union" that the U.S. make a counter-threat by using missile interceptors to hit any North Korean missile that is test-fired.

At each stop along his trip, Kerry stressed that the United States wanted a peaceful resolution of the North Korea situation six decades after a cease-fire ended the Korean War.

But North Korea on Sunday served a reminder of the difficult task ahead. Its Committee for the Peaceful Reunification of Korea said the government had no intention of talking with Seoul unless the South abandons its confrontational posture, as the North called it.

Seoul had pressed North Korea to discuss restarting operations at a joint factory park on the border and President Park Geun-hye has stressed peace opportunities after taking power from her more hard-line predecessor, Lee Myung-bak. The presidency expressed regret with North Korea's rebuttal Sunday.

At a news conference in Tokyo, Kerry stressed that gaining China's commitment to a denuclearized North Korea was no small matter given its historically strong military and economic ties to North Korea.

But he refused to say what the Chinese were offering to do concretely to pressure the North into abiding by some of the conditions it agreed to in a 2005 deal that required it to abandon its nuclear program.

"They have to take some actions," Kerry said of North Korea. "How many or how much? I'd have to talk to folks back in Washington about that. But if the Chinese came to us and said, 'Look, here's what we have cooking,' I'm not going to tell you I'm shutting the door today to something that's logical and might have a chance of success."

In remarks to U.S. journalists, Kerry said that under the right circumstances, he even would consider making a grand overture to North Korea's leader, such as an offer of direct talks with the U.S.

"We're prepared to reach out," he said. Diplomacy, he added, required risk-taking and secrecy such as when President Richard Nixon engaged China in the 1970s or U.S. back-channel talks were able to end the Cuban missile crisis a decade earlier.

Given their proximity and decades of hostility and distrust, Japan and South Korea have the most to fear from the North's unpredictable actions.

Kerry clarified a statement he made Saturday in Beijing, when he told reporters the U.S. could scale back its missile-defense posture in the region if North Korea goes nuclear-free.

It appeared to be a sweetener to coax tougher action from a Chinese government which has eyed the increased U.S. military presence in its backyard warily, but which has done little over the years to snuff out funding and support for North Korea's weapons of mass destruction program.

Kerry said America's basic force posture wasn't up to debate. "There is no discussion that I know of to change that," he said.

But he said it was logical that additional missile-defense elements, deployed specifically in response to the Korean threat, could be reversed if that threat no longer existed.

"I was simply making an observation about the rationale for that particular deployment, which is to protect the United States' interests that are directly threatened by North Korea," he said.

Source: http://news.yahoo.com/us-talks-diplomacy-nkorea-takes-hard-line-160454630--politics.html

ghost hunters lightsquared david lee honduras prison fire do not call list sports illustrated westminster dog show 2012

Could new flu spark global flu pandemic? New bird flu strain seen adapting to mammals, humans

Apr. 12, 2013 ? A genetic analysis of the avian flu virus responsible for at least nine human deaths in China portrays a virus evolving to adapt to human cells, raising concern about its potential to spark a new global flu pandemic.

The collaborative study, conducted by a group led by Masato Tashiro of the Influenza Virus Research Center, National Institute of Infectious Diseases, and Yoshihiro Kawaoka of the University of Wisconsin-Madison and the University of Tokyo, appears in the current edition (April 11, 2013) of the journal Eurosurveillance. The group examined the genetic sequences of H7N9 isolates from four of the pathogen's human victims as well as samples derived from birds and the environs of a Shanghai market.

"The human isolates, but not the avian and environmental ones, have a protein mutation that allows for efficient growth in human cells and that also allows them to grow at a temperature that corresponds to the upper respiratory tract of humans, which is lower than you find in birds," says Kawaoka, a leading expert on avian influenza.

The findings, drawn from genetic sequences deposited by Chinese researchers into an international database, provide some of the first molecular clues about a worrisome new strain of bird flu, the first human cases of which were reported on March 31 by the Chinese Center for Disease Control and Prevention. So far, the new virus has sickened at least 33 people, killing nine. Although it is too early to predict its potential to cause a pandemic, signs that the virus is adapting to mammalian and, in particular, human hosts are unmistakable, says Kawaoka.

Access to the genetic information in the viruses, he adds, is necessary for understanding how the virus is evolving and for developing a candidate vaccine to prevent infection.

Influenza virus depends on its ability to attach to and commandeer the living cells of its host to replicate and spread efficiently. Avian influenza rarely infects humans, but can sometimes adapt to people, posing a significant risk to human health.

"These viruses possess several characteristic features of mammalian influenza viruses, which likely contribute to their ability to infect humans and raise concerns regarding their pandemic potential," Kawaoka and his colleagues conclude in the Eurosurveillance report.

Kawaoka, a faculty member in the UW-Madison School of Veterinary Medicine who also holds a faculty appointment at the University of Tokyo, explains that the majority of the viruses in the study -- from both humans and birds -- display mutations in the surface protein hemagglutinin, which the pathogen uses to bind to host cells. Those mutations, according to Kawaoka, allowed them to easily infect human cells.

In addition, the isolates from patients contained another mutation that allows the virus to efficiently replicate inside human cells. The same mutation, Kawaoka notes, lets the avian virus thrive in the cooler temperatures of the human upper respiratory system. It is in the cells of the nose and throat that flu typically gains a hold in a mammalian or human host.

Kawaoka and his colleagues also assessed the response of the new strain to drugs used to treat influenza, discovering that one class of commonly used antiviral drugs, ion channel inhibitors which effectively bottle up the virus in the cell, would not be effective; the new strain could be treated with another clinically relevant antiviral drug, oseltamivir.

Share this story on Facebook, Twitter, and Google:

Other social bookmarking and sharing tools:


Story Source:

The above story is reprinted from materials provided by University of Wisconsin-Madison, via Newswise.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Kageyama T, Fujisaki S, Takashita E, Xu H, Yamada S, Uchida Y, Neumann G, Saito T, Kawaoka Y, Tashiro M. Genetic analysis of novel avian A(H7N9) influenza viruses isolated from patients in China, February to April 2013. Euro Surveill., 2013 [link]

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/living_well/~3/6D3PTlyJgDU/130412192402.htm

austin rivers sweet home alabama etch a sketch the host hoodie hoosiers temperance

San Francisco cable car accidents costs millions

SAN FRANCISCO (AP) ? In this city of innumerable tourist attractions, the clanging, hill-conquering cable cars stand out as a top draw.

The quaint conveyances also stand out for the inordinate number of accidents and the millions of dollars annually the city pays out to settle lawsuits for broken bones, severed feet and bad bruises caused when 19th-century technology runs headlong into 21st-century city traffic and congestion.

Cable cars average about an accident a month and routinely rank among the most accident-prone mass transportation modes in the country per vehicle mile traveled annually, according to the U.S. Department of Transportation. Over the last 10 years, city officials have reported 126 accidents injuring 151 people.

After the latest serious accident ? when seven people were injured after a cable car slammed to an unexpected stop after hitting a small bolt in the track ? The Associated Press obtained through a public records request a listing of cable car-related legal settlements over the last three years.

Those figures show the city paying nearly $8 million to settle about four dozen legal claims.

The city has paid on average $12 million annually to settle all claims connected to its mass transportation system that in addition to cable cars consists of electric street cars and buses, which travel many more miles and carry many more passengers.

City officials acknowledge that the open air cable cars, which ply only eight miles of track, produce a disproportionate amount of accident-related costs.

But they say the cars are a much beloved and valuable part of the city's life and character.

Their images are inscribed on the San Francisco Giants World Series rings. The cars have been immortalized in song and in television ads selling rice. And tourists line up dozens deep even in freezing weather for a chance to ride over the city's Nob and Russian hills.

"The iconic cable cars of San Francisco are a National Historic Landmark and we work every day to make them safer," San Francisco Mayor Ed Lee said, adding, "While accidents and injuries are down from just a few years ago, we are always working to improve the system as a whole."

Federal transportation figures show 19 injuries and 16 accidents last year, the second highest amount reported in the last 10 years. There were 36 accidents reported in 2004.

Two months ago, five passengers and two workers were injured after the bolt caused their cable car to slam to a sudden stop, tossing them violently inside the vehicle. The conductor had facial and tongue injuries and the driver suffered internal injuries and cracked ribs, transit officials said.

Legal claims are expected, as they always are after a cable car accident.

The city has been settling lawsuits almost since the cable cars began operation in 1893. One woman won a 1970 jury verdict of $50,000 after she claimed that a minor accident on a cable car she was riding turned her into a nymphomaniac.

"The 19th Century technology of the cable cars does pose some challenges," said Paul Rose, a spokesman for the city agency that oversees San Francisco mass transit. "While one accident is too many and we're always working to improve safety, these incidents are rare."

San Francisco remains the only place on the planet with a true, manually operated cable-car system serving the public.

First introduced in the late 1800s to save the strain on horses hauling carts up the city's steep inclines, the 15,500-pound cable-powered cars grip a continuously moving underground cable with pliers-like gear to travel the streets of San Francisco.

They are a San Francisco icon vital to the city's booming tourism industry.

A survey commissioned by the San Francisco Visitors and Conventions Bureau found the top four tourist activities in the city were dining, shopping, visiting museum and riding the cable cars. An estimated 7 million ride the cable cars annually, the vast majority tourists.

The biggest single payout over the last three years went to John Gainor, who received $3 million in November 2011 because his foot had to be amputated after it got caught between the cable car he was standing on and a parked vehicle.

Another $4 million went to the four victims of a runaway cable car that sped down a notoriously steep San Francisco hill before leaving the tracks and careening onto the sidewalk. The brakeman fell down outside the cable car as he was pushing it and couldn't get back aboard. A tourist from Texas suffered a broken femur and three others were seriously injured.

Linda Cvilikas, who tore tendons in her knee when a cable car she was riding came to a sudden halt on Nob Hill in 2011, said: "One minute I was standing and the next minute I was on top of my husband and a really large gentleman fell on top of me.

"That thing stopped and we all fell like dominoes," she said. The city paid Cvilikas $16,000 and her husband John another $2,500 to settle the Nebraska couple's legal claims. "It's safe to say that I won't be riding the cable cars again if I return to San Francisco," she said.

Source: http://news.yahoo.com/san-francisco-cable-car-accidents-costs-millions-185152433.html

daylight savings Daylight Savings Time 2013 DeAndre Jordan

Twitter tributes to Washington basketball coach Marv Harshman ...

Originally published April 12, 2013 at 1:03 PM | Page modified April 12, 2013 at 1:08 PM

Fans, players and coaches paid tribute to Marv Harshman after hearing news of his death at age 95.



Let's Get Digital

Let's Get Digital

Get unlimited access to seattletimes.com with your subscription. It's as easy as 1-2-3!

Advertising

Advertising

Source: http://seattletimes.com/html/sportspages/2020765551_harshman-twitter-tributes.html

marbury v. madison 2013 lincoln mkz burger king mary j blige google project glass google goggles one tree hill projectglass